FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017175281> ?p ?o ?g. }

• W2017175281 endingPage "8454" @default.
• W2017175281 startingPage "8443" @default.
• W2017175281 abstract "Replication Protein A (RPA) from human cells is a stable complex of 70-, 32-, and 14-kDa subunits that is required for multiple processes in DNA metabolism. RPA binds with high affinity to single-stranded DNA and interacts with multiple proteins, including proteins required for the initiation of SV40 DNA replication, DNA polymerase α and SV40 large T antigen. We have used a series of mutant derivatives of RPA to map the regions of RPA required for specific protein−protein interactions and have examined the roles of these interactions in DNA replication. T antigen, DNA polymerase α and the activation domain of VP16 all have overlapping sites of interaction in the N-terminal half (residues 1−327) of the 70-kDa subunit of RPA. In addition, the interaction site for DNA polymerase α is composed of two functionally distinct regions, one (residues 1−∼170) which stimulates polymerase activity and a second (residues ∼170−327) which increases polymerase processivity. In the latter, both the direct protein−protein interaction and ssDNA-binding activities of RPA were needed for RPA to modulate polymerase processivity. We also found that SV40 T antigen inhibited the ability of RPA to increase processivity of DNA polymerase α, suggesting that this activity of RPA may be important for elongation but not during the initiation of DNA replication. DNA polymerase α, but not T antigen also interacted with the 32- and/or 14-kDa subunits of RPA, but these interactions did not seem to effect polymerase activity." @default.
• W2017175281 created "2016-06-24" @default.
• W2017175281 creator A5025808337 @default.
• W2017175281 creator A5061973931 @default.
• W2017175281 creator A5066934827 @default.
• W2017175281 creator A5087322488 @default.
• W2017175281 creator A5088253635 @default.
• W2017175281 date "1997-07-01" @default.
• W2017175281 modified "2023-10-03" @default.
• W2017175281 title "Role of Protein−Protein Interactions in the Function of Replication Protein A (RPA): RPA Modulates the Activity of DNA Polymerase α by Multiple Mechanisms" @default.
• W2017175281 cites W1499161907 @default.
• W2017175281 cites W152730474 @default.
• W2017175281 cites W1533565768 @default.
• W2017175281 cites W1550656265 @default.
• W2017175281 cites W1558614105 @default.
• W2017175281 cites W1574209182 @default.
• W2017175281 cites W1590134197 @default.
• W2017175281 cites W1594126558 @default.
• W2017175281 cites W159450053 @default.
• W2017175281 cites W1605712430 @default.
• W2017175281 cites W1659681861 @default.
• W2017175281 cites W1828108619 @default.
• W2017175281 cites W1970456889 @default.
• W2017175281 cites W1979300852 @default.
• W2017175281 cites W1995806503 @default.
• W2017175281 cites W1999632568 @default.
• W2017175281 cites W2044614363 @default.
• W2017175281 cites W2050475314 @default.
• W2017175281 cites W2060850037 @default.
• W2017175281 cites W2062028908 @default.
• W2017175281 cites W2062373095 @default.
• W2017175281 cites W2068761725 @default.
• W2017175281 cites W2080170863 @default.
• W2017175281 cites W2134871100 @default.
• W2017175281 cites W2142844417 @default.
• W2017175281 cites W2169154093 @default.
• W2017175281 cites W2279382382 @default.
• W2017175281 cites W2413335087 @default.
• W2017175281 cites W4242690337 @default.
• W2017175281 cites W838635636 @default.
• W2017175281 doi "https://doi.org/10.1021/bi970473r" @default.
• W2017175281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9214288" @default.
• W2017175281 hasPublicationYear "1997" @default.
• W2017175281 type Work @default.
• W2017175281 sameAs 2017175281 @default.
• W2017175281 citedByCount "136" @default.
• W2017175281 countsByYear W20171752812012 @default.
• W2017175281 countsByYear W20171752812013 @default.
• W2017175281 countsByYear W20171752812014 @default.
• W2017175281 countsByYear W20171752812015 @default.
• W2017175281 countsByYear W20171752812016 @default.
• W2017175281 countsByYear W20171752812017 @default.
• W2017175281 countsByYear W20171752812018 @default.
• W2017175281 countsByYear W20171752812019 @default.
• W2017175281 countsByYear W20171752812020 @default.
• W2017175281 countsByYear W20171752812021 @default.
• W2017175281 countsByYear W20171752812022 @default.
• W2017175281 countsByYear W20171752812023 @default.
• W2017175281 crossrefType "journal-article" @default.
• W2017175281 hasAuthorship W2017175281A5025808337 @default.
• W2017175281 hasAuthorship W2017175281A5061973931 @default.
• W2017175281 hasAuthorship W2017175281A5066934827 @default.
• W2017175281 hasAuthorship W2017175281A5087322488 @default.
• W2017175281 hasAuthorship W2017175281A5088253635 @default.
• W2017175281 hasConcept C104317684 @default.
• W2017175281 hasConcept C113271649 @default.
• W2017175281 hasConcept C131140672 @default.
• W2017175281 hasConcept C153911025 @default.
• W2017175281 hasConcept C156719811 @default.
• W2017175281 hasConcept C164965036 @default.
• W2017175281 hasConcept C188036394 @default.
• W2017175281 hasConcept C2756471 @default.
• W2017175281 hasConcept C31254050 @default.
• W2017175281 hasConcept C34688535 @default.
• W2017175281 hasConcept C552990157 @default.
• W2017175281 hasConcept C55493867 @default.
• W2017175281 hasConcept C67705224 @default.
• W2017175281 hasConcept C73573662 @default.
• W2017175281 hasConcept C76535049 @default.
• W2017175281 hasConcept C82381507 @default.
• W2017175281 hasConcept C86339819 @default.
• W2017175281 hasConcept C86803240 @default.
• W2017175281 hasConcept C88354546 @default.
• W2017175281 hasConcept C94966510 @default.
• W2017175281 hasConcept C95444343 @default.
• W2017175281 hasConcept C98086919 @default.
• W2017175281 hasConceptScore W2017175281C104317684 @default.
• W2017175281 hasConceptScore W2017175281C113271649 @default.
• W2017175281 hasConceptScore W2017175281C131140672 @default.
• W2017175281 hasConceptScore W2017175281C153911025 @default.
• W2017175281 hasConceptScore W2017175281C156719811 @default.
• W2017175281 hasConceptScore W2017175281C164965036 @default.
• W2017175281 hasConceptScore W2017175281C188036394 @default.
• W2017175281 hasConceptScore W2017175281C2756471 @default.
• W2017175281 hasConceptScore W2017175281C31254050 @default.
• W2017175281 hasConceptScore W2017175281C34688535 @default.
• W2017175281 hasConceptScore W2017175281C552990157 @default.
• W2017175281 hasConceptScore W2017175281C55493867 @default.

• next