FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017176768> ?p ?o ?g. }

• W2017176768 endingPage "35587" @default.
• W2017176768 startingPage "35578" @default.
• W2017176768 abstract "Fatp4 exhibits acyl-CoA synthetase activity and is thereby able to catalyze the activation of fatty acids for further metabolism. However, its actual function in most tissues remains unresolved, and its role in cellular fatty acid uptake is still controversial. To characterize Fatp4 functions in adipocytes in vivo, we generated a mouse line with adipocyte-specific inactivation of the Fatp4 gene (Fatp4(A-/-)). Under standard conditions mutant mice showed no phenotypical aberrance. Uptake of radiolabeled palmitic and lignoceric acid into adipose tissue of Fatp4(A-/-) mice was unchanged. When exposed to a diet enriched in long chain fatty acids, Fatp4(A-/-) mice gained more body weight compared with control mice, although they were not consuming more food. Pronounced obesity was accompanied by a thicker layer of subcutaneous fat and greater adipocyte circumference, although expression of genes involved in de novo lipogenesis was not changed. However, the increase in total fat mass was contrasted by a significant decrease in various phospholipids, sphingomyelin, and cholesteryl esters in adipocytes. Livers of Fatp4-deficient animals under a high fat diet exhibited a higher degree of fatty degeneration. Nonetheless, no evidence for changes in insulin sensitivity and adipose inflammation was found. In summary, the results of this study confirm that Fatp4 is not crucial for fatty acid uptake into adipocytes. Instead, under the condition of a diet enriched in long chain fatty acids, adipocyte-specific Fatp4 deficiency results in adipose hypertrophy and profound alterations in the metabolism of complex lipids." @default.
• W2017176768 created "2016-06-24" @default.
• W2017176768 creator A5005915254 @default.
• W2017176768 creator A5013210540 @default.
• W2017176768 creator A5014422783 @default.
• W2017176768 creator A5016634905 @default.
• W2017176768 creator A5035719074 @default.
• W2017176768 creator A5036569602 @default.
• W2017176768 creator A5039129097 @default.
• W2017176768 creator A5042625397 @default.
• W2017176768 creator A5049156295 @default.
• W2017176768 creator A5070833222 @default.
• W2017176768 creator A5072719414 @default.
• W2017176768 creator A5083715777 @default.
• W2017176768 date "2011-10-01" @default.
• W2017176768 modified "2023-10-14" @default.
• W2017176768 title "Adipocyte-specific Inactivation of Acyl-CoA Synthetase Fatty Acid Transport Protein 4 (Fatp4) in Mice Causes Adipose Hypertrophy and Alterations in Metabolism of Complex Lipids under High Fat Diet" @default.
• W2017176768 cites W1967542934 @default.
• W2017176768 cites W1967849676 @default.
• W2017176768 cites W1973662608 @default.
• W2017176768 cites W1979165845 @default.
• W2017176768 cites W1979647427 @default.
• W2017176768 cites W1990159295 @default.
• W2017176768 cites W1992956691 @default.
• W2017176768 cites W2003372992 @default.
• W2017176768 cites W2023345325 @default.
• W2017176768 cites W2035327550 @default.
• W2017176768 cites W2051415594 @default.
• W2017176768 cites W2057101636 @default.
• W2017176768 cites W2057455189 @default.
• W2017176768 cites W2065478506 @default.
• W2017176768 cites W2068474082 @default.
• W2017176768 cites W2087133453 @default.
• W2017176768 cites W2088680600 @default.
• W2017176768 cites W2091930065 @default.
• W2017176768 cites W2130586614 @default.
• W2017176768 cites W2131008301 @default.
• W2017176768 cites W2133545915 @default.
• W2017176768 cites W2136943950 @default.
• W2017176768 cites W2147788805 @default.
• W2017176768 cites W2153287523 @default.
• W2017176768 cites W2154574357 @default.
• W2017176768 cites W2157843109 @default.
• W2017176768 cites W2158326572 @default.
• W2017176768 cites W2164277931 @default.
• W2017176768 cites W2169372815 @default.
• W2017176768 cites W2171952619 @default.
• W2017176768 cites W4238497443 @default.
• W2017176768 doi "https://doi.org/10.1074/jbc.m111.226530" @default.
• W2017176768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3195640" @default.
• W2017176768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21808061" @default.
• W2017176768 hasPublicationYear "2011" @default.
• W2017176768 type Work @default.
• W2017176768 sameAs 2017176768 @default.
• W2017176768 citedByCount "41" @default.
• W2017176768 countsByYear W20171767682012 @default.
• W2017176768 countsByYear W20171767682013 @default.
• W2017176768 countsByYear W20171767682014 @default.
• W2017176768 countsByYear W20171767682015 @default.
• W2017176768 countsByYear W20171767682017 @default.
• W2017176768 countsByYear W20171767682018 @default.
• W2017176768 countsByYear W20171767682019 @default.
• W2017176768 countsByYear W20171767682020 @default.
• W2017176768 countsByYear W20171767682021 @default.
• W2017176768 countsByYear W20171767682022 @default.
• W2017176768 countsByYear W20171767682023 @default.
• W2017176768 crossrefType "journal-article" @default.
• W2017176768 hasAuthorship W2017176768A5005915254 @default.
• W2017176768 hasAuthorship W2017176768A5013210540 @default.
• W2017176768 hasAuthorship W2017176768A5014422783 @default.
• W2017176768 hasAuthorship W2017176768A5016634905 @default.
• W2017176768 hasAuthorship W2017176768A5035719074 @default.
• W2017176768 hasAuthorship W2017176768A5036569602 @default.
• W2017176768 hasAuthorship W2017176768A5039129097 @default.
• W2017176768 hasAuthorship W2017176768A5042625397 @default.
• W2017176768 hasAuthorship W2017176768A5049156295 @default.
• W2017176768 hasAuthorship W2017176768A5070833222 @default.
• W2017176768 hasAuthorship W2017176768A5072719414 @default.
• W2017176768 hasAuthorship W2017176768A5083715777 @default.
• W2017176768 hasBestOaLocation W20171767681 @default.
• W2017176768 hasConcept C126322002 @default.
• W2017176768 hasConcept C134018914 @default.
• W2017176768 hasConcept C140985366 @default.
• W2017176768 hasConcept C141359234 @default.
• W2017176768 hasConcept C151955695 @default.
• W2017176768 hasConcept C171089720 @default.
• W2017176768 hasConcept C185592680 @default.
• W2017176768 hasConcept C24972589 @default.
• W2017176768 hasConcept C2776175234 @default.
• W2017176768 hasConcept C2776941171 @default.
• W2017176768 hasConcept C2776991927 @default.
• W2017176768 hasConcept C4733338 @default.
• W2017176768 hasConcept C543025807 @default.
• W2017176768 hasConcept C55493867 @default.
• W2017176768 hasConcept C71924100 @default.
• W2017176768 hasConcept C82714985 @default.
• W2017176768 hasConcept C86803240 @default.
• W2017176768 hasConceptScore W2017176768C126322002 @default.

• next