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- W2017178464 abstract "Abstract Monooxygenase activities, epoxide hydrolase, and glutathione S -transferase activities were measured in fractions prepared from pooled livers of three small estuarine fish species, Fundulus grandis, Cyprinodon variegatus , and Poecilia latipinna , and three freshwater species, Oryzias latipes, Peocilia reticulata , and Pimephales promelas . Interspecies differences in xenobiotic metabolizing activities of up to 10-fold were observed, with the smaller freshwater species generally having lower activities than the estuarine species. Groups of each species were injected with microliter volumes of corn oil or a solution of 3-methylcholanthrene (3MC) in corn oil, and enzyme activities measured 4–5 days later in pooled liver fractions from control or 3MC-treated fish. Although statistical analysis of induction effects was not possible, monooxygenase activities with ethoxyresorufin and benzo( a )pyrene were 2.5–15 times higher in 3MC-treated fish than in corn oil or untreated control groups. In 3MC-treated C. variegatus and F. grandis , microsomal cytochrome P-450 content was doubled and the spectral maximum of the CO-reduced microsomes was shifted from 449.6 to 448.5 nm. Microsomes from 3MC-treated C. variegatus and F. grandis metabolized benzo( a )pyrene 5–6 times faster than controls (per mg protein), but the proportion of 9,10- and 7,8-dihydrodiol metabolites was lower in 3MC-treated fish, suggesting that epoxide hydrolase may be rate limiting for production of dihydrodiols. 3MC treatment did not alter styrene oxide hydrolase or glutathione S -transferase activities at the time point tested." @default.
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- W2017178464 title "Effect of 3-methylcholanthrene on monooxygenase, epoxide hydrolase, and glutathione S-transferase activities in small estuarine and freshwater fish" @default.
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- W2017178464 doi "https://doi.org/10.1016/0166-445x(88)90015-x" @default.
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