FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017180838> ?p ?o ?g. }

• W2017180838 endingPage "2144" @default.
• W2017180838 startingPage "2136" @default.
• W2017180838 abstract "The bacterial topoisomerase II (DNA gyrase) and the mammalian topoisomerase II represent the cellular targets for quinolone antibacterials and a wide variety of anticancer drugs, respectively. In view of the mechanistic similarities and sequence homologies exhibited by the two enzymes, tentative efforts to selectively shift from an antibacterial to an antitumoral activity was made by synthesizing a series of modified tricyclic quinolones, in which the essential 3-carboxylic function is surrogated by phenolic OH and the classic C-6 fluorine atom is replaced by a NH2 group. The resulting 7-amino-9-acridone derivatives were assayed for their antibacterial as well as cytotoxic activities. No antibacterial activity was found. On the other hand, many derivatives showed significant cytotoxic activity against both HL-60 and P388 leukemias and a wide panel of human and rodent solid tumor cells, derivatives 25 and 26 displaying the best overall antiproliferative activity. Against the LoVo cell line, derivative 25 exhibited higher cytotoxic effects than etoposide." @default.
• W2017180838 created "2016-06-24" @default.
• W2017180838 creator A5010835490 @default.
• W2017180838 creator A5018559181 @default.
• W2017180838 creator A5024776063 @default.
• W2017180838 creator A5041624355 @default.
• W2017180838 creator A5043864360 @default.
• W2017180838 creator A5057923752 @default.
• W2017180838 creator A5070881182 @default.
• W2017180838 creator A5075876145 @default.
• W2017180838 date "1999-05-29" @default.
• W2017180838 modified "2023-09-23" @default.
• W2017180838 title "Design and Synthesis of Modified Quinolones as Antitumoral Acridones" @default.
• W2017180838 cites W1996007131 @default.
• W2017180838 cites W1997919079 @default.
• W2017180838 cites W2001121050 @default.
• W2017180838 cites W2008248447 @default.
• W2017180838 cites W2014891765 @default.
• W2017180838 cites W2014976849 @default.
• W2017180838 cites W2016254453 @default.
• W2017180838 cites W2027611515 @default.
• W2017180838 cites W2035016164 @default.
• W2017180838 cites W2043524438 @default.
• W2017180838 cites W2050557086 @default.
• W2017180838 cites W2062014388 @default.
• W2017180838 cites W2068120117 @default.
• W2017180838 cites W2085263798 @default.
• W2017180838 cites W2109201263 @default.
• W2017180838 cites W2114918609 @default.
• W2017180838 cites W2141593791 @default.
• W2017180838 cites W2147746526 @default.
• W2017180838 cites W2171672489 @default.
• W2017180838 cites W2313377632 @default.
• W2017180838 cites W2364762990 @default.
• W2017180838 cites W2949870156 @default.
• W2017180838 cites W2951466773 @default.
• W2017180838 doi "https://doi.org/10.1021/jm980324m" @default.
• W2017180838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10377219" @default.
• W2017180838 hasPublicationYear "1999" @default.
• W2017180838 type Work @default.
• W2017180838 sameAs 2017180838 @default.
• W2017180838 citedByCount "32" @default.
• W2017180838 countsByYear W20171808382013 @default.
• W2017180838 countsByYear W20171808382014 @default.
• W2017180838 countsByYear W20171808382015 @default.
• W2017180838 countsByYear W20171808382016 @default.
• W2017180838 countsByYear W20171808382018 @default.
• W2017180838 countsByYear W20171808382019 @default.
• W2017180838 countsByYear W20171808382020 @default.
• W2017180838 countsByYear W20171808382022 @default.
• W2017180838 crossrefType "journal-article" @default.
• W2017180838 hasAuthorship W2017180838A5010835490 @default.
• W2017180838 hasAuthorship W2017180838A5018559181 @default.
• W2017180838 hasAuthorship W2017180838A5024776063 @default.
• W2017180838 hasAuthorship W2017180838A5041624355 @default.
• W2017180838 hasAuthorship W2017180838A5043864360 @default.
• W2017180838 hasAuthorship W2017180838A5057923752 @default.
• W2017180838 hasAuthorship W2017180838A5070881182 @default.
• W2017180838 hasAuthorship W2017180838A5075876145 @default.
• W2017180838 hasConcept C104317684 @default.
• W2017180838 hasConcept C109316439 @default.
• W2017180838 hasConcept C147897179 @default.
• W2017180838 hasConcept C154317977 @default.
• W2017180838 hasConcept C167125095 @default.
• W2017180838 hasConcept C181199279 @default.
• W2017180838 hasConcept C185592680 @default.
• W2017180838 hasConcept C202751555 @default.
• W2017180838 hasConcept C2776694085 @default.
• W2017180838 hasConcept C2777112418 @default.
• W2017180838 hasConcept C2777482282 @default.
• W2017180838 hasConcept C2778119113 @default.
• W2017180838 hasConcept C2779922871 @default.
• W2017180838 hasConcept C2780104969 @default.
• W2017180838 hasConcept C2781081902 @default.
• W2017180838 hasConcept C3019249092 @default.
• W2017180838 hasConcept C501593827 @default.
• W2017180838 hasConcept C523546767 @default.
• W2017180838 hasConcept C54355233 @default.
• W2017180838 hasConcept C547475151 @default.
• W2017180838 hasConcept C55493867 @default.
• W2017180838 hasConcept C71240020 @default.
• W2017180838 hasConcept C86803240 @default.
• W2017180838 hasConceptScore W2017180838C104317684 @default.
• W2017180838 hasConceptScore W2017180838C109316439 @default.
• W2017180838 hasConceptScore W2017180838C147897179 @default.
• W2017180838 hasConceptScore W2017180838C154317977 @default.
• W2017180838 hasConceptScore W2017180838C167125095 @default.
• W2017180838 hasConceptScore W2017180838C181199279 @default.
• W2017180838 hasConceptScore W2017180838C185592680 @default.
• W2017180838 hasConceptScore W2017180838C202751555 @default.
• W2017180838 hasConceptScore W2017180838C2776694085 @default.
• W2017180838 hasConceptScore W2017180838C2777112418 @default.
• W2017180838 hasConceptScore W2017180838C2777482282 @default.
• W2017180838 hasConceptScore W2017180838C2778119113 @default.
• W2017180838 hasConceptScore W2017180838C2779922871 @default.
• W2017180838 hasConceptScore W2017180838C2780104969 @default.
• W2017180838 hasConceptScore W2017180838C2781081902 @default.
• W2017180838 hasConceptScore W2017180838C3019249092 @default.

• next