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- W2017181503 abstract "Acetylcholinesterase (AChE)can be released in the Perfusate of rat caudate nucleus (CN) slices by two different modes of stimulation, with electrical stimulation at 5Hz and with high concentrations of K+ (105 mM) using K+ -propionate. We were unable to demonstrate AChE release with lower K+ concentrations (50 mM); however, at this concentration the drop in AChEactivity seen in resting conditions was prevented. Practicfallyb all (95%) cholinesterase (ChE)found in the rat CN is AChE, which is reprersented by tow major molecular forms (4S and 10S). In the perfusate, only AChE activity could be detected. A comparison of acetylcholine (ACh) and AChE release showed that maximal 3H-outflow and AChE release occurred at the same frequency (5 Hz), but the onsetof AChE release was delayed. With high K+ (105mM) depolarization, AChE release started after termination of the stimulation and continued for at least 50 min. These findings are consistent with the view that soluble form(s) of AChE can be slowly released from neurons under specific conditions of depolarization. In the caudate of the rat, the most likely sites for this release are processes of chlinergic interneurons. A hypothesis of AChE release is presented, and possible physiological and pathological implications of such a mechanism are discussed." @default.
- W2017181503 created "2016-06-24" @default.
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- W2017181503 date "1987-01-01" @default.
- W2017181503 modified "2023-09-27" @default.
- W2017181503 title "Release of acetylcholinesterase from the caudate nucleus of the rat" @default.
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- W2017181503 doi "https://doi.org/10.1002/jnr.490180411" @default.
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