FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017184561> ?p ?o ?g. }

• W2017184561 endingPage "881" @default.
• W2017184561 startingPage "874" @default.
• W2017184561 abstract "Reflux of duodenal contents into the esophagus of patients with gastroesophageal reflux disease has been suggested by pH and bilirubin monitoring but is rarely directly measured. A portable device has been developed and was used to collect and quantitate material refluxed into the esophagus under ambulatory conditions during a prolonged time period. The objective of this study was to use this device to quantitate the composition and concentration of bile acids refluxed into the esophagus of patients with gastroesophageal reflux disease.Esophageal aspiration was performed on 43 normal subjects and 37 patients with reflux disease during a 17-hour period. Aspiration was performed through a modified 16F Salem sump tube, positioned 5 cm above the lower esophageal sphincter and connected to a portable, battery powered pump that aspirated continuously at 100 mm Hg pressure. Validation studies showed that minimal amounts of saliva and swallowed liquids were aspirated and that gastric pressure was not altered. Postprandial, upright, and supine collections were performed. Total bile acids were assayed by a standard enzymatic assay; specific conjugated bile acids were analyzed by high-performance liquid chromatography.There was no difference in the total aspiration volume between normal volunteers and patients with gastroesophageal reflux disease, although patients tended to have a higher volume in the supine and postprandial periods. Bile acids could be detected in 58% of normal subjects and 86% of patients (p < 0.003). The mean concentration of bile salt exposure (micromole per liter) was higher in patients during the postprandial and supine periods. The mean bile acid reflux rate (micromole per hour) during all three aspiration periods was significantly higher in patients. On a molar basis the composition of the bile acids was 60% glycocholic acid, 16% glycodeoxycholic acid, and 15% glycochenodeoxycholic acid. Taurocholic, taurodeoxycholic, taurochenodeoxycholic, and glycolithocholic acid constituted the remaining 10%.Patients with reflux disease have an increased concentration of bile acids in their esophageal aspirates. Most of the exposure occurs during the postprandial and supine periods. A variety of bile acids were detected, most of which were in their glycine conjugated form." @default.
• W2017184561 created "2016-06-24" @default.
• W2017184561 creator A5020843186 @default.
• W2017184561 creator A5038615871 @default.
• W2017184561 creator A5048746660 @default.
• W2017184561 creator A5057251337 @default.
• W2017184561 creator A5057525086 @default.
• W2017184561 creator A5069666525 @default.
• W2017184561 creator A5089328800 @default.
• W2017184561 date "1997-11-01" @default.
• W2017184561 modified "2023-09-30" @default.
• W2017184561 title "Composition and concentration of bile acid reflux into the esophagus of patients with gastroesophageal reflux disease" @default.
• W2017184561 cites W1562359707 @default.
• W2017184561 cites W1744924361 @default.
• W2017184561 cites W1974572767 @default.
• W2017184561 cites W1989654033 @default.
• W2017184561 cites W2016283312 @default.
• W2017184561 cites W2042733540 @default.
• W2017184561 cites W2061070986 @default.
• W2017184561 cites W2063688926 @default.
• W2017184561 cites W2074476123 @default.
• W2017184561 cites W2092655157 @default.
• W2017184561 cites W2103431993 @default.
• W2017184561 cites W2113989649 @default.
• W2017184561 cites W2337059216 @default.
• W2017184561 cites W2588888741 @default.
• W2017184561 doi "https://doi.org/10.1016/s0039-6060(97)90327-5" @default.
• W2017184561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9369886" @default.
• W2017184561 hasPublicationYear "1997" @default.
• W2017184561 type Work @default.
• W2017184561 sameAs 2017184561 @default.
• W2017184561 citedByCount "186" @default.
• W2017184561 countsByYear W20171845612012 @default.
• W2017184561 countsByYear W20171845612013 @default.
• W2017184561 countsByYear W20171845612014 @default.
• W2017184561 countsByYear W20171845612015 @default.
• W2017184561 countsByYear W20171845612016 @default.
• W2017184561 countsByYear W20171845612017 @default.
• W2017184561 countsByYear W20171845612018 @default.
• W2017184561 countsByYear W20171845612019 @default.
• W2017184561 countsByYear W20171845612020 @default.
• W2017184561 countsByYear W20171845612021 @default.
• W2017184561 countsByYear W20171845612022 @default.
• W2017184561 countsByYear W20171845612023 @default.
• W2017184561 crossrefType "journal-article" @default.
• W2017184561 hasAuthorship W2017184561A5020843186 @default.
• W2017184561 hasAuthorship W2017184561A5038615871 @default.
• W2017184561 hasAuthorship W2017184561A5048746660 @default.
• W2017184561 hasAuthorship W2017184561A5057251337 @default.
• W2017184561 hasAuthorship W2017184561A5057525086 @default.
• W2017184561 hasAuthorship W2017184561A5069666525 @default.
• W2017184561 hasAuthorship W2017184561A5089328800 @default.
• W2017184561 hasConcept C125567185 @default.
• W2017184561 hasConcept C126322002 @default.
• W2017184561 hasConcept C2777819096 @default.
• W2017184561 hasConcept C2778199505 @default.
• W2017184561 hasConcept C2779134260 @default.
• W2017184561 hasConcept C2779306644 @default.
• W2017184561 hasConcept C2779399885 @default.
• W2017184561 hasConcept C43270747 @default.
• W2017184561 hasConcept C71924100 @default.
• W2017184561 hasConcept C90924648 @default.
• W2017184561 hasConceptScore W2017184561C125567185 @default.
• W2017184561 hasConceptScore W2017184561C126322002 @default.
• W2017184561 hasConceptScore W2017184561C2777819096 @default.
• W2017184561 hasConceptScore W2017184561C2778199505 @default.
• W2017184561 hasConceptScore W2017184561C2779134260 @default.
• W2017184561 hasConceptScore W2017184561C2779306644 @default.
• W2017184561 hasConceptScore W2017184561C2779399885 @default.
• W2017184561 hasConceptScore W2017184561C43270747 @default.
• W2017184561 hasConceptScore W2017184561C71924100 @default.
• W2017184561 hasConceptScore W2017184561C90924648 @default.
• W2017184561 hasIssue "5" @default.
• W2017184561 hasLocation W20171845611 @default.
• W2017184561 hasLocation W20171845612 @default.
• W2017184561 hasOpenAccess W2017184561 @default.
• W2017184561 hasPrimaryLocation W20171845611 @default.
• W2017184561 hasRelatedWork W1505265370 @default.
• W2017184561 hasRelatedWork W1988480115 @default.
• W2017184561 hasRelatedWork W2022311620 @default.
• W2017184561 hasRelatedWork W2076707606 @default.
• W2017184561 hasRelatedWork W2089020254 @default.
• W2017184561 hasRelatedWork W2157386577 @default.
• W2017184561 hasRelatedWork W2337059216 @default.
• W2017184561 hasRelatedWork W2418584167 @default.
• W2017184561 hasRelatedWork W3027933993 @default.
• W2017184561 hasRelatedWork W3029171470 @default.
• W2017184561 hasVolume "122" @default.
• W2017184561 isParatext "false" @default.
• W2017184561 isRetracted "false" @default.
• W2017184561 magId "2017184561" @default.
• W2017184561 workType "article" @default.