FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017187788> ?p ?o ?g. }

• W2017187788 endingPage "345" @default.
• W2017187788 startingPage "337" @default.
• W2017187788 abstract "Genetic changes related to colorectal carcinomas are accumulated in individual tumor glands during disease progression. Microsatellite allelic analysis of individual tumor glands from 30 colorectal carcinomas using a polymerase chain reaction (PCR) assay coupled with crypt isolation was used to detect intratumoral genetic heterogeneity, the sequence of allelic imbalances (AIs) and the microsatellite instability status of single tumor glands during neoplastic progression. In addition, the CpG islands methylated phenotype (CIMP) status was examined using a methylation-specific PCR method. The specimens were divided into 2 groups: a pooled gland sample, which was composed of more than 50 tumor glands, and a single tumor gland sample. The latter consisted of 10 single tumor glands, which were obtained from the same tumor separately. Most colorectal carcinomas (27 of 30 tumors) examined were heterogeneous for at least one genetic alteration, with from 2 to 7 genotypically different subclones detected per tumor. In 12 of the 27 heterogeneous tumors, it was possible to define the order of genetic alterations during the tumor progression. By analyzing multiple single tumor glands within the same tumor, we found that various subclonal expansions were seen within the same tumors. Finally, the AI pattern of single tumor glands was not correlated with CIMP status. Most carcinomas appeared to have a heterogeneous composition. This may have resulted from the successful progression of one clone that had different AIs in many chromosomal regions. This suggests that knowledge of the different genotypes of multiple single tumor glands may help clarify the process of tumor progression. © 2004 Wiley-Liss, Inc." @default.
• W2017187788 created "2016-06-24" @default.
• W2017187788 creator A5015183700 @default.
• W2017187788 creator A5018567359 @default.
• W2017187788 creator A5043530344 @default.
• W2017187788 creator A5069753860 @default.
• W2017187788 creator A5071747755 @default.
• W2017187788 creator A5071975010 @default.
• W2017187788 creator A5084820122 @default.
• W2017187788 creator A5088527994 @default.
• W2017187788 date "2005-01-01" @default.
• W2017187788 modified "2023-10-16" @default.
• W2017187788 title "Analysis of allelic imbalances at multiple cancer-related chromosomal loci and microsatellite instability within the same tumor using a single tumor gland from colorectal carcinomas" @default.
• W2017187788 cites W1530977725 @default.
• W2017187788 cites W1544851750 @default.
• W2017187788 cites W1670317346 @default.
• W2017187788 cites W1964129698 @default.
• W2017187788 cites W1967304777 @default.
• W2017187788 cites W1982107639 @default.
• W2017187788 cites W1992373240 @default.
• W2017187788 cites W2000435171 @default.
• W2017187788 cites W2001258296 @default.
• W2017187788 cites W2023344315 @default.
• W2017187788 cites W2027312402 @default.
• W2017187788 cites W2035416339 @default.
• W2017187788 cites W2037466369 @default.
• W2017187788 cites W2041109622 @default.
• W2017187788 cites W2041263849 @default.
• W2017187788 cites W2068400261 @default.
• W2017187788 cites W2068897967 @default.
• W2017187788 cites W2074279306 @default.
• W2017187788 cites W2075407747 @default.
• W2017187788 cites W2079335506 @default.
• W2017187788 cites W2080308138 @default.
• W2017187788 cites W2081628031 @default.
• W2017187788 cites W2088987931 @default.
• W2017187788 cites W2091723114 @default.
• W2017187788 cites W2128146359 @default.
• W2017187788 cites W2175072937 @default.
• W2017187788 cites W4245952570 @default.
• W2017187788 doi "https://doi.org/10.1002/ijc.20689" @default.
• W2017187788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15578702" @default.
• W2017187788 hasPublicationYear "2005" @default.
• W2017187788 type Work @default.
• W2017187788 sameAs 2017187788 @default.
• W2017187788 citedByCount "10" @default.
• W2017187788 countsByYear W20171877882012 @default.
• W2017187788 countsByYear W20171877882015 @default.
• W2017187788 countsByYear W20171877882016 @default.
• W2017187788 countsByYear W20171877882017 @default.
• W2017187788 crossrefType "journal-article" @default.
• W2017187788 hasAuthorship W2017187788A5015183700 @default.
• W2017187788 hasAuthorship W2017187788A5018567359 @default.
• W2017187788 hasAuthorship W2017187788A5043530344 @default.
• W2017187788 hasAuthorship W2017187788A5069753860 @default.
• W2017187788 hasAuthorship W2017187788A5071747755 @default.
• W2017187788 hasAuthorship W2017187788A5071975010 @default.
• W2017187788 hasAuthorship W2017187788A5084820122 @default.
• W2017187788 hasAuthorship W2017187788A5088527994 @default.
• W2017187788 hasBestOaLocation W20171877881 @default.
• W2017187788 hasConcept C104317684 @default.
• W2017187788 hasConcept C121608353 @default.
• W2017187788 hasConcept C140752955 @default.
• W2017187788 hasConcept C142724271 @default.
• W2017187788 hasConcept C143589142 @default.
• W2017187788 hasConcept C180754005 @default.
• W2017187788 hasConcept C2779013556 @default.
• W2017187788 hasConcept C2779256057 @default.
• W2017187788 hasConcept C2779767149 @default.
• W2017187788 hasConcept C2780283643 @default.
• W2017187788 hasConcept C30481170 @default.
• W2017187788 hasConcept C502942594 @default.
• W2017187788 hasConcept C526805850 @default.
• W2017187788 hasConcept C54355233 @default.
• W2017187788 hasConcept C61320498 @default.
• W2017187788 hasConcept C71924100 @default.
• W2017187788 hasConcept C86803240 @default.
• W2017187788 hasConceptScore W2017187788C104317684 @default.
• W2017187788 hasConceptScore W2017187788C121608353 @default.
• W2017187788 hasConceptScore W2017187788C140752955 @default.
• W2017187788 hasConceptScore W2017187788C142724271 @default.
• W2017187788 hasConceptScore W2017187788C143589142 @default.
• W2017187788 hasConceptScore W2017187788C180754005 @default.
• W2017187788 hasConceptScore W2017187788C2779013556 @default.
• W2017187788 hasConceptScore W2017187788C2779256057 @default.
• W2017187788 hasConceptScore W2017187788C2779767149 @default.
• W2017187788 hasConceptScore W2017187788C2780283643 @default.
• W2017187788 hasConceptScore W2017187788C30481170 @default.
• W2017187788 hasConceptScore W2017187788C502942594 @default.
• W2017187788 hasConceptScore W2017187788C526805850 @default.
• W2017187788 hasConceptScore W2017187788C54355233 @default.
• W2017187788 hasConceptScore W2017187788C61320498 @default.
• W2017187788 hasConceptScore W2017187788C71924100 @default.
• W2017187788 hasConceptScore W2017187788C86803240 @default.
• W2017187788 hasIssue "3" @default.
• W2017187788 hasLocation W20171877881 @default.
• W2017187788 hasLocation W20171877882 @default.
• W2017187788 hasOpenAccess W2017187788 @default.

• next