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- W2017189129 abstract "Our ability to perceive, attend, and memorize depends on bidirectional information exchange between hierarchically organized brain areas. Areas lower in the hierarchy send information through feedforward connections to higher areas. Higher areas modulate the activity in lower areas by means of feedback connections, and thereby influence the local processing as well as the information they receive. Although this scheme is well accepted, the exact role of feedforward and feedback connections in cognition is still poorly understood, let alone the mechanisms by which they mediate their effects. A report by Self et al. (1) in PNAS sheds light on the mechanisms involved. They delineate the different receptor types that contribute to feedforward and to feedback processing. They recorded neuronal activity from macaque primary visual cortex (V1) while animals performed a figure-ground detection task. V1 neurons in awake animals show differential activity depending on whether they represent the figure (2, 3) or whether they represent the background, even if the image within their receptive field is identical under both conditions. This differential activity is known as figure-ground modulation, and it depends …" @default.
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- W2017189129 title "NMDA receptors figure it out" @default.
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- W2017189129 doi "https://doi.org/10.1073/pnas.1207975109" @default.
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