FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017190795> ?p ?o ?g. }

• W2017190795 endingPage "71" @default.
• W2017190795 startingPage "66" @default.
• W2017190795 abstract "Astrocyte apoptosis occurs in acute and chronic pathological processes at the central nervous system and the prevention of astrocyte death may represent an efficacious intervention in protecting neurons against degeneration. Our research shows that rat astrocyte exposure to 100 nM staurosporine for 3 h caused apoptotic death accompanied by caspase-3, p38 mitogen-ed protein kinase (MAPK) and glycogen synthase kinase-3β (GSK3β) activation. N6-chlorocyclopentyladenosine (CCPA, 2.5–75 nM), a selective agonist of A1 adenosine receptors, added to the cultures 1 h prior to staurosporine, induced a dose-dependent anti-apoptotic effect, which was inhibited by the A1 receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine. CCPA also caused a dose- and time-dependent phosphorylation/activation of Akt, a downstream effector of cell survival promoting phosphatidylinositol 3-kinase (PI3K) pathway, which in turn led to inhibition of staurosporine-induced GSK3β and p38 MAPK activity. Accordingly, the anti-apoptotic effect of CCPA was abolished by culture pre-treatment with LY294002, a selective PI3K inhibitor, pointing out the prevailing role played by PI3K pathway in the protective effect exerted by A1 receptor activation. Since an abnormal p38 and GSK3β activity is implicated in acute (stroke) and chronic (Alzheimer's disease) neurodegenerative diseases, the results of the present study provide a hint to better understand adenosine relevance in these disorders." @default.
• W2017190795 created "2016-06-24" @default.
• W2017190795 creator A5003811151 @default.
• W2017190795 creator A5016711153 @default.
• W2017190795 creator A5037309586 @default.
• W2017190795 creator A5043450015 @default.
• W2017190795 creator A5044837831 @default.
• W2017190795 creator A5045124300 @default.
• W2017190795 creator A5051971085 @default.
• W2017190795 creator A5091374060 @default.
• W2017190795 date "2007-05-01" @default.
• W2017190795 modified "2023-10-03" @default.
• W2017190795 title "Staurosporine-induced apoptosis in astrocytes is prevented by A1 adenosine receptor activation" @default.
• W2017190795 cites W1575672758 @default.
• W2017190795 cites W1890393292 @default.
• W2017190795 cites W1976385326 @default.
• W2017190795 cites W1981196417 @default.
• W2017190795 cites W1982444570 @default.
• W2017190795 cites W1985460150 @default.
• W2017190795 cites W1990511593 @default.
• W2017190795 cites W1995062961 @default.
• W2017190795 cites W2000989128 @default.
• W2017190795 cites W2002613500 @default.
• W2017190795 cites W2004700698 @default.
• W2017190795 cites W2014415555 @default.
• W2017190795 cites W2028580069 @default.
• W2017190795 cites W2031042637 @default.
• W2017190795 cites W2034831207 @default.
• W2017190795 cites W2047864808 @default.
• W2017190795 cites W2048121649 @default.
• W2017190795 cites W2053265248 @default.
• W2017190795 cites W2058138221 @default.
• W2017190795 cites W2070732456 @default.
• W2017190795 cites W2072586423 @default.
• W2017190795 cites W2076104235 @default.
• W2017190795 cites W2076206556 @default.
• W2017190795 cites W2118092399 @default.
• W2017190795 cites W2124896688 @default.
• W2017190795 cites W2125904354 @default.
• W2017190795 cites W2133064784 @default.
• W2017190795 cites W4321429312 @default.
• W2017190795 doi "https://doi.org/10.1016/j.neulet.2007.02.061" @default.
• W2017190795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17400382" @default.
• W2017190795 hasPublicationYear "2007" @default.
• W2017190795 type Work @default.
• W2017190795 sameAs 2017190795 @default.
• W2017190795 citedByCount "36" @default.
• W2017190795 countsByYear W20171907952012 @default.
• W2017190795 countsByYear W20171907952013 @default.
• W2017190795 countsByYear W20171907952014 @default.
• W2017190795 countsByYear W20171907952015 @default.
• W2017190795 countsByYear W20171907952016 @default.
• W2017190795 countsByYear W20171907952018 @default.
• W2017190795 countsByYear W20171907952019 @default.
• W2017190795 countsByYear W20171907952021 @default.
• W2017190795 countsByYear W20171907952022 @default.
• W2017190795 countsByYear W20171907952023 @default.
• W2017190795 crossrefType "journal-article" @default.
• W2017190795 hasAuthorship W2017190795A5003811151 @default.
• W2017190795 hasAuthorship W2017190795A5016711153 @default.
• W2017190795 hasAuthorship W2017190795A5037309586 @default.
• W2017190795 hasAuthorship W2017190795A5043450015 @default.
• W2017190795 hasAuthorship W2017190795A5044837831 @default.
• W2017190795 hasAuthorship W2017190795A5045124300 @default.
• W2017190795 hasAuthorship W2017190795A5051971085 @default.
• W2017190795 hasAuthorship W2017190795A5091374060 @default.
• W2017190795 hasConcept C134018914 @default.
• W2017190795 hasConcept C170493617 @default.
• W2017190795 hasConcept C184235292 @default.
• W2017190795 hasConcept C2776912716 @default.
• W2017190795 hasConcept C2776991684 @default.
• W2017190795 hasConcept C2777542381 @default.
• W2017190795 hasConcept C2778938600 @default.
• W2017190795 hasConcept C2779084600 @default.
• W2017190795 hasConcept C2781225136 @default.
• W2017190795 hasConcept C529278444 @default.
• W2017190795 hasConcept C55493867 @default.
• W2017190795 hasConcept C57074206 @default.
• W2017190795 hasConcept C62478195 @default.
• W2017190795 hasConcept C67907053 @default.
• W2017190795 hasConcept C75217442 @default.
• W2017190795 hasConcept C86554907 @default.
• W2017190795 hasConcept C86803240 @default.
• W2017190795 hasConcept C95444343 @default.
• W2017190795 hasConcept C97029542 @default.
• W2017190795 hasConcept C98274493 @default.
• W2017190795 hasConceptScore W2017190795C134018914 @default.
• W2017190795 hasConceptScore W2017190795C170493617 @default.
• W2017190795 hasConceptScore W2017190795C184235292 @default.
• W2017190795 hasConceptScore W2017190795C2776912716 @default.
• W2017190795 hasConceptScore W2017190795C2776991684 @default.
• W2017190795 hasConceptScore W2017190795C2777542381 @default.
• W2017190795 hasConceptScore W2017190795C2778938600 @default.
• W2017190795 hasConceptScore W2017190795C2779084600 @default.
• W2017190795 hasConceptScore W2017190795C2781225136 @default.
• W2017190795 hasConceptScore W2017190795C529278444 @default.
• W2017190795 hasConceptScore W2017190795C55493867 @default.
• W2017190795 hasConceptScore W2017190795C57074206 @default.

• next