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• W20171909 abstract "Abstract Blast cells from patients with acute myeloblastic leukemia were exposed to 5-azacytidine (5-aza) and its analogues 5-aza 2′-deoxycytidine (5- aza-dr) and 6-azacytidine (6-aza). Simple negative exponential survival curves were obtained for the three drugs, but the sensitivity varied; 5- aza-dr was most toxic, 6-aza was least toxic, and 5-aza was intermediate. Colonies surviving drug exposure were replated; 5-aza and 5-aza-dr were found to increase secondary plating efficiency, whereas 6- aza was inactive. The findings provide indirect evidence for a role for DNA methylation in the regulation of blast cell self-renewal." @default.
• W20171909 created "2016-06-24" @default.
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• W20171909 date "1985-04-01" @default.
• W20171909 modified "2023-10-02" @default.
• W20171909 title "The effect of 5-azacytidine and its analogues on blast cell renewal in acute myeloblastic leukemia" @default.
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• W20171909 doi "https://doi.org/10.1182/blood.v65.4.894.894" @default.
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