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- W2017192914 abstract "Abstract In the past five years there has been a steady accumulation of evidence that lithium inhibits aggressive behavior in man. 1–4 The most recent and complete study employed a double-blind design and reported the effect of lithium versus placebo on 16–24 year old incarcerated male delinquents. 5 A significant reduction in threatening or assaultive behavior was found in the lithium-treated group. We now describe in detail four individual case studies from the lithium-treated group in the double-blind study. We feel these four cases exemplify representative types of lithium responsive subjects. For the purposes of this paper a “lithium responder” is defined as a subject who received at least two institutionally-administered penalties for threatening or violent behavior (“major infractions”) during the predrug control period, and had a reduction of at least two major infractions while on lithium. Of 34 lithium subjects, 11 met the control period criterion, and 9 of these met the responder criterion; of 32 placebo subjects, 7 met the control period and 1, the responder criterion. The 4 individuals discussed here showed an unambiguous improvement in their overall ability to control overt violent aggressive behavior while on lithium. The literature contains several individual case studies of the effects of lithium on “aggressive” behavior. Some of the features of these cases taken together with those found in our study serve as a basis for identifying clinical criteria which warrant a trial of lithium in certain types of exaggerated aggressive behavior in man." @default.
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- W2017192914 date "1978-01-01" @default.
- W2017192914 modified "2023-09-27" @default.
- W2017192914 title "Treatment of human aggressive behavior: Four case studies of the effect of lithium" @default.
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- W2017192914 doi "https://doi.org/10.1016/0010-440x(78)90030-5" @default.
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