Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017193677> ?p ?o ?g. }
- W2017193677 endingPage "196" @default.
- W2017193677 startingPage "187" @default.
- W2017193677 abstract "Zn2+ is present at high concentrations in the synaptic vesicles of hippocampal mossy fibers. We have used Zn2+ chelators and the mocha mutant mouse to address the physiological role of Zn2+ in this pathway. Zn2+ is not involved in the unique presynaptic plasticities observed at mossy fiber synapses but is coreleased with glutamate from these synapses, both spontaneously and with electrical stimulation, where it exerts a strong modulatory effect on the NMDA receptors. Zn2+ tonically occupies the high-affinity binding site of NMDA receptors at mossy fiber synapses, whereas the lower affinity voltage-dependent Zn2+ binding site is occupied during action potential driven-release. We conclude that Zn2+ is a modulatory neurotransmitter released from mossy fiber synapses and plays an important role in shaping the NMDA receptor response at these synapses." @default.
- W2017193677 created "2016-06-24" @default.
- W2017193677 creator A5023011366 @default.
- W2017193677 creator A5032659348 @default.
- W2017193677 creator A5053859273 @default.
- W2017193677 creator A5054104648 @default.
- W2017193677 date "2000-04-01" @default.
- W2017193677 modified "2023-10-10" @default.
- W2017193677 title "The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses" @default.
- W2017193677 cites W1567544633 @default.
- W2017193677 cites W157666778 @default.
- W2017193677 cites W1607231292 @default.
- W2017193677 cites W1656913045 @default.
- W2017193677 cites W1691996697 @default.
- W2017193677 cites W1873773379 @default.
- W2017193677 cites W1966995589 @default.
- W2017193677 cites W1967143047 @default.
- W2017193677 cites W1969167894 @default.
- W2017193677 cites W1970564284 @default.
- W2017193677 cites W1975070097 @default.
- W2017193677 cites W1979565874 @default.
- W2017193677 cites W1985220401 @default.
- W2017193677 cites W1990557260 @default.
- W2017193677 cites W1991647860 @default.
- W2017193677 cites W1993097538 @default.
- W2017193677 cites W1995054580 @default.
- W2017193677 cites W1996456984 @default.
- W2017193677 cites W2003282397 @default.
- W2017193677 cites W2004007082 @default.
- W2017193677 cites W2008122915 @default.
- W2017193677 cites W2011480808 @default.
- W2017193677 cites W2016979211 @default.
- W2017193677 cites W2017878571 @default.
- W2017193677 cites W2018883950 @default.
- W2017193677 cites W2022862769 @default.
- W2017193677 cites W2026590190 @default.
- W2017193677 cites W2026815588 @default.
- W2017193677 cites W2035089473 @default.
- W2017193677 cites W2037677380 @default.
- W2017193677 cites W2041128903 @default.
- W2017193677 cites W2044926585 @default.
- W2017193677 cites W2044981704 @default.
- W2017193677 cites W2046423382 @default.
- W2017193677 cites W2048116173 @default.
- W2017193677 cites W2051401596 @default.
- W2017193677 cites W2055775269 @default.
- W2017193677 cites W2056925277 @default.
- W2017193677 cites W2070251156 @default.
- W2017193677 cites W2077122729 @default.
- W2017193677 cites W2077476035 @default.
- W2017193677 cites W2086294041 @default.
- W2017193677 cites W2094811107 @default.
- W2017193677 cites W2116328062 @default.
- W2017193677 cites W2117088111 @default.
- W2017193677 cites W2159976043 @default.
- W2017193677 cites W2166291087 @default.
- W2017193677 cites W2169063473 @default.
- W2017193677 cites W97375708 @default.
- W2017193677 doi "https://doi.org/10.1016/s0896-6273(00)81149-6" @default.
- W2017193677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10798403" @default.
- W2017193677 hasPublicationYear "2000" @default.
- W2017193677 type Work @default.
- W2017193677 sameAs 2017193677 @default.
- W2017193677 citedByCount "453" @default.
- W2017193677 countsByYear W20171936772012 @default.
- W2017193677 countsByYear W20171936772013 @default.
- W2017193677 countsByYear W20171936772014 @default.
- W2017193677 countsByYear W20171936772015 @default.
- W2017193677 countsByYear W20171936772016 @default.
- W2017193677 countsByYear W20171936772017 @default.
- W2017193677 countsByYear W20171936772018 @default.
- W2017193677 countsByYear W20171936772019 @default.
- W2017193677 countsByYear W20171936772020 @default.
- W2017193677 countsByYear W20171936772021 @default.
- W2017193677 countsByYear W20171936772022 @default.
- W2017193677 countsByYear W20171936772023 @default.
- W2017193677 crossrefType "journal-article" @default.
- W2017193677 hasAuthorship W2017193677A5023011366 @default.
- W2017193677 hasAuthorship W2017193677A5032659348 @default.
- W2017193677 hasAuthorship W2017193677A5053859273 @default.
- W2017193677 hasAuthorship W2017193677A5054104648 @default.
- W2017193677 hasBestOaLocation W20171936771 @default.
- W2017193677 hasConcept C12554922 @default.
- W2017193677 hasConcept C127445978 @default.
- W2017193677 hasConcept C130316041 @default.
- W2017193677 hasConcept C148762608 @default.
- W2017193677 hasConcept C148785051 @default.
- W2017193677 hasConcept C169760540 @default.
- W2017193677 hasConcept C170493617 @default.
- W2017193677 hasConcept C185592680 @default.
- W2017193677 hasConcept C2776219046 @default.
- W2017193677 hasConcept C2776464000 @default.
- W2017193677 hasConcept C2777318268 @default.
- W2017193677 hasConcept C41625074 @default.
- W2017193677 hasConcept C529278444 @default.
- W2017193677 hasConcept C55493867 @default.
- W2017193677 hasConcept C61174792 @default.
- W2017193677 hasConcept C67018056 @default.