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• W2017194328 abstract "Abstract To a cell, chosen at random from a given cell population, there is associated a transition probability function, constituting a measure of the expected probability of that cell irreversibly to leave the population within a short time interval. The transition probability function is considered as a time-independent function of the age of the cell, and it is shown how this function, under some general restrictive conditions, completely determines the behaviour of the whole system. Theoretically, the treatment may be reversed, which means that any survival curve, when generated by some kind of an irreversible transition, can always be interpreted in terms of a transition probability function. The results indicate certain principles as regards the general methodology. As an example is outlined a possible mechanism of the transition of reticulocytes to red blood cells, showing how a purely physical hypothesis may indicate the form of the transition probability function; the results are compared with some experimental data taken from the literature. However, it is claimed that such a detailed physical interpretation of the transition probability function involves certain problems, calling for further theoretical work." @default.
• W2017194328 created "2016-06-24" @default.
• W2017194328 creator A5029059713 @default.
• W2017194328 date "1962-05-01" @default.
• W2017194328 modified "2023-10-02" @default.
• W2017194328 title "On the stochastic interpretation of cell survival curves" @default.
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• W2017194328 doi "https://doi.org/10.1016/0022-5193(62)90031-0" @default.
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