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• W2017194914 abstract "We have investigated the cellular distribution of p122RhoGAP, a GTPase-activating protein of Rho small GTPase and an activator of phospholipase C-delta(1). Immunofluorescence studies demonstrated that endogenous p122 is localized at the tips of actin stress fibres and co-localizes with vinculin in normal rat kidney cells. In immunoprecipitation studies, p122 co-precipitated with vinculin, indicating that p122 is localized at the sites of focal adhesion. We have also shown that the N-terminal half of p122 is responsible for this localization. It is conceivable, therefore, that p122 is involved in the reorganization of the actin cytoskeleton and focal adhesions that regulate cell-substratum adhesion and cell migration." @default.
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• W2017194914 date "2004-10-26" @default.
• W2017194914 modified "2023-10-16" @default.
• W2017194914 title "A PLCδ1-binding protein, p122RhoGAP, is localized in focal adhesions" @default.
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• W2017194914 doi "https://doi.org/10.1042/bst0321107" @default.
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