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- W2017201998 abstract "Summary Aim Remote ischemic preconditioning protects against ischemic organ damage by giving short periods of subcritical ischemia to a remote organ. We tested the hypothesis that remote ischemic conditioning can attenuate cerebral stroke in a rat middle cerebral artery occlusion ( MCAO ) model by microparticles ( MP s). Methods and results MPs were extracted from healthy rats that underwent hindlimb ischemia–reperfusion preconditioning (RIPC), and were transfused into rats that had undergone MCAO without RIPC. The transfusion resulted in an increase in platelet‐derived MPs in blood and reduction in infarction area, confirmed by both 2‐3‐5‐triphenyltetrazolium chloride staining and magnetic resonance imaging, albeit to a lesser degree than RIPC itself. Behavioral tests (modified Neurological Severity Score [ mNSS ]) were calculated to judge the behavioral change. However, no significant difference was observed after MP transfusion in 24 h or the following consecutive 9 days. Conclusions RIPC induces an increase in MP s, and platelet‐derived MP s may confer at least part of the remote protective effect against cerebral ischemic–reperfusion injury." @default.
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- W2017201998 date "2013-11-04" @default.
- W2017201998 modified "2023-10-13" @default.
- W2017201998 title "Platelet-Derived Microparticles are Implicated in Remote Ischemia Conditioning in a Rat Model of Cerebral Infarction" @default.
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- W2017201998 doi "https://doi.org/10.1111/cns.12199" @default.
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