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• W2017206105 abstract "Francisella tularensis is a highly virulent pathogenic bacterium. In order to identify novel potential antibacterial agents against F. tularensis, libraries of trisubstituted benzimidazoles were screened against F. tularensis LVS strain. In a preliminary screening assay, remarkably, 23 of 2,5,6- and 2,5,7-trisubstituted benzimidazoles showed excellent activity exhibiting greater than 90% growth inhibition at 1 μg/mL. Among those hits, 21 compounds showed MIC90 values in the range of 0.35–48.6 μg/mL after accurate MIC determination. In ex vivo efficacy assays, four of these compounds exhibited 2–3 log reduction in colony forming units (CFU) per mL at concentrations of 10 and 50 μg/mL." @default.
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• W2017206105 date "2013-06-01" @default.
• W2017206105 modified "2023-09-23" @default.
• W2017206105 title "Benzimidazole-based antibacterial agents against Francisella tularensis" @default.
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• W2017206105 doi "https://doi.org/10.1016/j.bmc.2013.02.059" @default.
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