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- W201720651 abstract "ABSTRACT. In Neurospora crassa two early reactions in the constitutive common aromatic (polyaromatic) synthetic pathway exhibit interesting interrelationships with comparable early reactions in the inducible quinate-shikimate (hydroaromatic) catabolic pathway. Genetical and biochemical evidence indicates that this organism possesses two pairs of isozymes in the two pathways—two dehydroquinases and two shikimate oxidoreductases. Normally, one member of each pair functions in the biosynthetic pathway and the other in the catabolic pathway. However, under certain conditions, the two DHQases can substitute for one another in vivo, while the catabolic (NAD) oxidoreductase can substitute for the biosynthetic (NADP) oxidoreductase. Even mutants lacking both biosynthetic enzymes can (under certain conditions) utilize the two catabolic isozymes to grow without a polyaromatic supplement. These results indicate interesting functional similarities between the two pairs of enzymes and suggest possible evolutionary relatedness. However, at this stage in the evolution of the N. crassa genome, the two pairs of activities are encoded in quite separate genetic material—two unlinked gene clusters (the arom and qa clusters) and the two biosynthetic activities are part of a multienzyme complex (the arom complex). At present no evidence exists concerning possible amino acid homologies between the two pairs of isozymes." @default.
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- W201720651 title "TWO PAIRS OF ISOZYMES IN THE AROMATIC BIOSYNTHETIC AND CATABOLIC PATHWAYS IN NEUROSPORA CRASSA" @default.
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