FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017207200> ?p ?o ?g. }

• W2017207200 endingPage "77" @default.
• W2017207200 startingPage "72" @default.
• W2017207200 abstract "We have demonstrated that protein kinase Cδ (PKCδ) could be involved in macrophage apoptosis induced by cationic liposomes composed of stearylamine (SA-liposomes), but the detailed mechanism of how SA-liposomes activate PKCδ has remained unclear. In this paper, we clarified whether lipid rafts are involved in the PKCδ activation induced by SA-liposomes. Co-localization of SA-liposomes and Cholera toxin B subunit (CBT), which specifically binds to ganglioside GM1 on lipid rafts, was found by microscopic observation. The incorporation of SA-liposomes into lipid rafts was clearly inhibited by the pretreatment of cells with an agent, 2,6-di-O-methyl-α-cyclodextrin (DM-α-CD) which disrupts lipid rafts. Activation of PKCδ and externalization of phosphatidylserine induced by SA-liposomes were also suppressed by DM-α-CD, which extracts sphingolipids and proteins from lipid rafts. Reactive oxygen species (ROS) generation, which could be involved in the macrophage apoptosis, was also inhibited by DM-α-CD. Furthermore, apoptosis induced by SA-liposomes was clearly inhibited when the cells were pre-treated with DM-α-CD, but not nystatin, a cholesterol-sequestering agent that disrupt lipid rafts. These findings suggest that sphingolipids in lipid rafts are involved in the activation of PKCδ which leads to apoptosis induced by cationic liposomes, SA-liposomes." @default.
• W2017207200 created "2016-06-24" @default.
• W2017207200 creator A5022790895 @default.
• W2017207200 creator A5047234038 @default.
• W2017207200 creator A5055510329 @default.
• W2017207200 creator A5073259164 @default.
• W2017207200 creator A5086855818 @default.
• W2017207200 date "2011-04-01" @default.
• W2017207200 modified "2023-09-26" @default.
• W2017207200 title "Involvement of lipid rafts in macrophage apoptosis induced by cationic liposomes" @default.
• W2017207200 cites W1581889893 @default.
• W2017207200 cites W1784927340 @default.
• W2017207200 cites W1978148007 @default.
• W2017207200 cites W1980591945 @default.
• W2017207200 cites W1984307295 @default.
• W2017207200 cites W1988742771 @default.
• W2017207200 cites W1991862967 @default.
• W2017207200 cites W1991863218 @default.
• W2017207200 cites W1995889983 @default.
• W2017207200 cites W1997266942 @default.
• W2017207200 cites W2006910800 @default.
• W2017207200 cites W2018233812 @default.
• W2017207200 cites W2025033116 @default.
• W2017207200 cites W207574618 @default.
• W2017207200 cites W2091077321 @default.
• W2017207200 cites W2093847817 @default.
• W2017207200 cites W2110051182 @default.
• W2017207200 cites W2137835070 @default.
• W2017207200 cites W2151603054 @default.
• W2017207200 cites W25236442 @default.
• W2017207200 cites W304834860 @default.
• W2017207200 cites W60424123 @default.
• W2017207200 doi "https://doi.org/10.1016/j.abb.2011.02.003" @default.
• W2017207200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21315683" @default.
• W2017207200 hasPublicationYear "2011" @default.
• W2017207200 type Work @default.
• W2017207200 sameAs 2017207200 @default.
• W2017207200 citedByCount "12" @default.
• W2017207200 countsByYear W20172072002012 @default.
• W2017207200 countsByYear W20172072002013 @default.
• W2017207200 countsByYear W20172072002015 @default.
• W2017207200 countsByYear W20172072002017 @default.
• W2017207200 countsByYear W20172072002019 @default.
• W2017207200 crossrefType "journal-article" @default.
• W2017207200 hasAuthorship W2017207200A5022790895 @default.
• W2017207200 hasAuthorship W2017207200A5047234038 @default.
• W2017207200 hasAuthorship W2017207200A5055510329 @default.
• W2017207200 hasAuthorship W2017207200A5073259164 @default.
• W2017207200 hasAuthorship W2017207200A5086855818 @default.
• W2017207200 hasConcept C104317684 @default.
• W2017207200 hasConcept C155887181 @default.
• W2017207200 hasConcept C184235292 @default.
• W2017207200 hasConcept C185154212 @default.
• W2017207200 hasConcept C185592680 @default.
• W2017207200 hasConcept C190283241 @default.
• W2017207200 hasConcept C195794163 @default.
• W2017207200 hasConcept C2777006276 @default.
• W2017207200 hasConcept C2777331542 @default.
• W2017207200 hasConcept C2778163477 @default.
• W2017207200 hasConcept C2778918659 @default.
• W2017207200 hasConcept C2779637612 @default.
• W2017207200 hasConcept C41625074 @default.
• W2017207200 hasConcept C48349386 @default.
• W2017207200 hasConcept C54009773 @default.
• W2017207200 hasConcept C55493867 @default.
• W2017207200 hasConcept C61705674 @default.
• W2017207200 hasConcept C79266657 @default.
• W2017207200 hasConcept C86803240 @default.
• W2017207200 hasConcept C89423630 @default.
• W2017207200 hasConcept C95444343 @default.
• W2017207200 hasConceptScore W2017207200C104317684 @default.
• W2017207200 hasConceptScore W2017207200C155887181 @default.
• W2017207200 hasConceptScore W2017207200C184235292 @default.
• W2017207200 hasConceptScore W2017207200C185154212 @default.
• W2017207200 hasConceptScore W2017207200C185592680 @default.
• W2017207200 hasConceptScore W2017207200C190283241 @default.
• W2017207200 hasConceptScore W2017207200C195794163 @default.
• W2017207200 hasConceptScore W2017207200C2777006276 @default.
• W2017207200 hasConceptScore W2017207200C2777331542 @default.
• W2017207200 hasConceptScore W2017207200C2778163477 @default.
• W2017207200 hasConceptScore W2017207200C2778918659 @default.
• W2017207200 hasConceptScore W2017207200C2779637612 @default.
• W2017207200 hasConceptScore W2017207200C41625074 @default.
• W2017207200 hasConceptScore W2017207200C48349386 @default.
• W2017207200 hasConceptScore W2017207200C54009773 @default.
• W2017207200 hasConceptScore W2017207200C55493867 @default.
• W2017207200 hasConceptScore W2017207200C61705674 @default.
• W2017207200 hasConceptScore W2017207200C79266657 @default.
• W2017207200 hasConceptScore W2017207200C86803240 @default.
• W2017207200 hasConceptScore W2017207200C89423630 @default.
• W2017207200 hasConceptScore W2017207200C95444343 @default.
• W2017207200 hasIssue "1" @default.
• W2017207200 hasLocation W20172072001 @default.
• W2017207200 hasLocation W20172072002 @default.
• W2017207200 hasOpenAccess W2017207200 @default.
• W2017207200 hasPrimaryLocation W20172072001 @default.
• W2017207200 hasRelatedWork W1217530789 @default.
• W2017207200 hasRelatedWork W1965605134 @default.

• next