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• W2017207687 abstract "Diabetes/Metabolism Research and ReviewsVolume 23, Issue 4 p. 255-256 Editorial Immuno-intervention and preservation of beta-cell function in type 1 diabetes Paolo Pozzilli, Corresponding Author Paolo Pozzilli [email protected] University Campus Bio-Medico, Via Longoni 83, 00135 Rome, ItalyUniversity Campus Bio-Medico, Via Longoni 83, 00135 Rome, Italy.Search for more papers by this author Paolo Pozzilli, Corresponding Author Paolo Pozzilli [email protected] University Campus Bio-Medico, Via Longoni 83, 00135 Rome, ItalyUniversity Campus Bio-Medico, Via Longoni 83, 00135 Rome, Italy.Search for more papers by this author First published: 02 May 2007 https://doi.org/10.1002/dmrr.746Citations: 3Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. References 1Yoon JW, Jun HS. Autoimmune destruction of pancreatic beta cells. Am J Ther 2005; 12(6): 580– 591. 2Goudy KS, Tisch R. Immunotherapy for the prevention and treatment of type 1 diabetes. Int Rev Immunol 2005; 24(5–6): 307– 326. 3Bekris LM, Kavanagh TJ, Lernmark A. Targeting type 1 diabetes before and at the clinical onset of disease. Endocr Metabol Immune Disord Drug Targets 2006; 6(1): 103– 124. 4Figueredo A, Ibarra JL, Rodriguez A, et al. Increased serum levels of IgA antibodies to hsp70 protein in patients with diabetes mellitus: their relationship with vascular complications. Clin Immunol Immunopathol 1996; 79(3): 252– 255. 5Nussbaum G, Zanin-Zhorov A, Quintana F, Lider O, Cohen IR. Peptide p277 of HSP60 signals T cells: inhibition of inflammatory chemotaxis. Immunol 2006; 18(10): 1413– 1419. 6Ozawa Y, Kasuga A, Nomaguchi H, et al. Detection of autoantibodies to the pancreatic islet heat shock protein 60 in insulin-dependent diabetes mellitus. J Autoimmun 1996; 9(4): 517– 524. 7Cohen IR. Peptide therapy for Type I diabetes: the immunological homunculus and the rationale for vaccination. Diabetologia 2002; 45: 1468– 1474. 8Elias D, Meilin A, Ablamunits V, et al. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and down-regulates autoimmunity to various beta-cell antigens. Diabetes 1997; 46: 758– 764. 9Horvath L, Cervenak L, Oroszlan M, et al. Antibodies against different epitopes of heat-shock protein 60 in children with type 1 diabetes mellitus. Immunol Lett 2002; 80(3): 155– 162. 10Brugman S, Klatter FA, Visser J, Bos NA, Elias D, Rozing J. Neonatal oral administration of DiaPep277, combined with hydrolysed casein diet, protects against Type 1 diabetes in BB-DP rats. An experimental study. Diabetologia 2004; 47(7): 1331– 1333. 11Elias D, Raz I, Avron A, et al. Treatment of new-onset type 1 diabetes with peptide DiaPep277® is safe and associated with preserved beta-cell function: extension of a randomised, double-blind, phase II trial. Diabetes Metab Res Rev 2007; 23: 292– 298. 12Roep B, Huurman V, Decochez K, Mathieu C, Cohen I. Therapy with the hsp60 peptide DiaPep277™ in C-peptide positive type 1 diabetes patients. Diabetes Metab Res Rev 2007; 23: 269– 275. 13Schloot N, Meierhoff G, Lengyel C, et al. Effect of heat shock protein peptide DiaPep277 on ß-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomised, double blind phase II trials. Diabetes Metab Res Rev 2007; 23: 276– 285. 14Lazar L, Ofan R, Weintrob N, et al. Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: a randomised, double-blind phase II study. Diabetes Metab Res Rev 2007; 23: 286– 291. 15Raz I, Elias D, Avron A, Tamir M, Metzger M, Cohen IR. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 2001; 358(9295): 1749– 1753. 16Keymeulen B, Vandemeulebroucke E, Ziegler AG, et al. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 2005; 352(25): 2598– 2608. 17Pozzilli P, Crino A, Schiaffini R, et al, The IMDIAB Group. A 2-year pilot trial of continuous subcutaneous insulin infusion versus intensive insulin therapy in patients with newly diagnosed type 1 diabetes (IMDIAB 8). Diabetes Technol Ther 2003; 5(6): 965– 974. Citing Literature Volume23, Issue4May/June 2007Pages 255-256 ReferencesRelatedInformation" @default.
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