FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017208305> ?p ?o ?g. }

• W2017208305 endingPage "1335" @default.
• W2017208305 startingPage "1329" @default.
• W2017208305 abstract "Apoptosis can be mediated by mechanisms other than the traditional caspase-mediated cleavage cascade. There is growing recognition that alternative proteolytic enzymes such as the lysosomal cathepsin proteases can initiate or propagate proapoptotic signals, but it is currently unclear how cathepsins achieve these actions. Recent in vitro evidence suggests that cathepsins cleave the proapoptotic Bcl-2 family member Bid, thereby activating it and allowing it to induce the mitochondrial release of cytochrome c and subsequent apoptosis. We have tested this hypothesis in vivo by breeding mice that lack cathepsin inhibition (cystatin B-deficient mice) to Bid-deficient mice, to determine whether the apoptosis caused by cathepsins is dependent on Bid signaling. We found that cathepsins are still able to promote apoptosis even in the absence of Bid, indicating that these proteases mediate apoptosis via a different pathway, or that some other molecule can functionally substitute for Bid in this system." @default.
• W2017208305 created "2016-06-24" @default.
• W2017208305 creator A5015092247 @default.
• W2017208305 creator A5023059517 @default.
• W2017208305 creator A5030493071 @default.
• W2017208305 creator A5050811686 @default.
• W2017208305 creator A5056440307 @default.
• W2017208305 creator A5059319489 @default.
• W2017208305 date "2003-08-08" @default.
• W2017208305 modified "2023-10-07" @default.
• W2017208305 title "Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1)" @default.
• W2017208305 cites W1593219141 @default.
• W2017208305 cites W1598794829 @default.
• W2017208305 cites W1616910822 @default.
• W2017208305 cites W1890027265 @default.
• W2017208305 cites W1894006267 @default.
• W2017208305 cites W1973424870 @default.
• W2017208305 cites W1978841975 @default.
• W2017208305 cites W2012173926 @default.
• W2017208305 cites W2012361667 @default.
• W2017208305 cites W2018803810 @default.
• W2017208305 cites W2019631673 @default.
• W2017208305 cites W2026211921 @default.
• W2017208305 cites W2028111124 @default.
• W2017208305 cites W2035119142 @default.
• W2017208305 cites W2037030307 @default.
• W2017208305 cites W2045935725 @default.
• W2017208305 cites W2053305234 @default.
• W2017208305 cites W2058616596 @default.
• W2017208305 cites W2060137381 @default.
• W2017208305 cites W2062853648 @default.
• W2017208305 cites W2066052096 @default.
• W2017208305 cites W2068254519 @default.
• W2017208305 cites W2076107014 @default.
• W2017208305 cites W2076961896 @default.
• W2017208305 cites W2079071356 @default.
• W2017208305 cites W2085908746 @default.
• W2017208305 cites W2092884999 @default.
• W2017208305 cites W2098160574 @default.
• W2017208305 cites W2105958334 @default.
• W2017208305 cites W2120633856 @default.
• W2017208305 cites W2122482353 @default.
• W2017208305 cites W2134158036 @default.
• W2017208305 cites W2134388096 @default.
• W2017208305 cites W2135233980 @default.
• W2017208305 cites W2142120946 @default.
• W2017208305 cites W2159627505 @default.
• W2017208305 cites W2161275159 @default.
• W2017208305 cites W2325862576 @default.
• W2017208305 cites W4212779470 @default.
• W2017208305 cites W4240361153 @default.
• W2017208305 cites W973899072 @default.
• W2017208305 doi "https://doi.org/10.1038/sj.cdd.4401309" @default.
• W2017208305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12934064" @default.
• W2017208305 hasPublicationYear "2003" @default.
• W2017208305 type Work @default.
• W2017208305 sameAs 2017208305 @default.
• W2017208305 citedByCount "62" @default.
• W2017208305 countsByYear W20172083052012 @default.
• W2017208305 countsByYear W20172083052013 @default.
• W2017208305 countsByYear W20172083052014 @default.
• W2017208305 countsByYear W20172083052015 @default.
• W2017208305 countsByYear W20172083052016 @default.
• W2017208305 countsByYear W20172083052017 @default.
• W2017208305 countsByYear W20172083052019 @default.
• W2017208305 countsByYear W20172083052020 @default.
• W2017208305 countsByYear W20172083052022 @default.
• W2017208305 crossrefType "journal-article" @default.
• W2017208305 hasAuthorship W2017208305A5015092247 @default.
• W2017208305 hasAuthorship W2017208305A5023059517 @default.
• W2017208305 hasAuthorship W2017208305A5030493071 @default.
• W2017208305 hasAuthorship W2017208305A5050811686 @default.
• W2017208305 hasAuthorship W2017208305A5056440307 @default.
• W2017208305 hasAuthorship W2017208305A5059319489 @default.
• W2017208305 hasBestOaLocation W20172083051 @default.
• W2017208305 hasConcept C151701858 @default.
• W2017208305 hasConcept C167844969 @default.
• W2017208305 hasConcept C173633252 @default.
• W2017208305 hasConcept C181199279 @default.
• W2017208305 hasConcept C182220744 @default.
• W2017208305 hasConcept C190283241 @default.
• W2017208305 hasConcept C207001950 @default.
• W2017208305 hasConcept C28021979 @default.
• W2017208305 hasConcept C31573885 @default.
• W2017208305 hasConcept C54355233 @default.
• W2017208305 hasConcept C55493867 @default.
• W2017208305 hasConcept C86803240 @default.
• W2017208305 hasConcept C95444343 @default.
• W2017208305 hasConcept C98424977 @default.
• W2017208305 hasConceptScore W2017208305C151701858 @default.
• W2017208305 hasConceptScore W2017208305C167844969 @default.
• W2017208305 hasConceptScore W2017208305C173633252 @default.
• W2017208305 hasConceptScore W2017208305C181199279 @default.
• W2017208305 hasConceptScore W2017208305C182220744 @default.
• W2017208305 hasConceptScore W2017208305C190283241 @default.
• W2017208305 hasConceptScore W2017208305C207001950 @default.
• W2017208305 hasConceptScore W2017208305C28021979 @default.
• W2017208305 hasConceptScore W2017208305C31573885 @default.

• next