FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017209085> ?p ?o ?g. }

• W2017209085 endingPage "2847" @default.
• W2017209085 startingPage "2840" @default.
• W2017209085 abstract "In experimental allergic encephalomyelitis (EAE), CD4+ T cells infiltrate the central nervous system (CNS). We derived CD4+ T cell lines from SJL/J mice that were specific for encephalitogenic myelin basic protein (MBP) peptides and produced both Th1 and Th2 cytokines. These lines transferred EAE to naive mice. Peptide-specific cells re-isolated from the CNS only produced Th1 cytokines, whereas T cells in the lymph nodes produced both Th1 and Th2 cytokines. Mononuclear cells isolated from the CNS, the majority of which were microglia, presented antigen to and stimulated MBP-specific T cell lines in vitro. Although CNS antigen-presenting cells (APC) supported increased production of interferon (IFN)-gamma mRNA by these T cells, there was no increase in the interleukin (IL)-4 signal, whereas splenic APC induced increases in both IFN-gamma and IL-4. mRNA for IL-12 (p40 subunit) was up-regulated in both infiltrating macrophages and resident microglia from mice with EAE. We have thus shown that a Th1 cytokine bias within the CNS can be induced by CNS APC, and that IL-12 is up-regulated in microglial cells within the CNS of mice with EAE. Microglia may therefore control Th1 cytokine responses within the CNS." @default.
• W2017209085 created "2016-06-24" @default.
• W2017209085 creator A5054164188 @default.
• W2017209085 creator A5055253279 @default.
• W2017209085 date "1997-11-01" @default.
• W2017209085 modified "2023-10-14" @default.
• W2017209085 title "The central nervous system environment controls effector CD4+ T cell cytokine profile in experimental allergic encephalomyelitis" @default.
• W2017209085 cites W1498789037 @default.
• W2017209085 cites W1512112524 @default.
• W2017209085 cites W1561485846 @default.
• W2017209085 cites W1585833237 @default.
• W2017209085 cites W1641259203 @default.
• W2017209085 cites W1984921956 @default.
• W2017209085 cites W1991218414 @default.
• W2017209085 cites W1992985178 @default.
• W2017209085 cites W1995644527 @default.
• W2017209085 cites W1995700626 @default.
• W2017209085 cites W1996693750 @default.
• W2017209085 cites W1998121841 @default.
• W2017209085 cites W2003651898 @default.
• W2017209085 cites W2006048914 @default.
• W2017209085 cites W2010259789 @default.
• W2017209085 cites W2012295587 @default.
• W2017209085 cites W2018876280 @default.
• W2017209085 cites W2040838085 @default.
• W2017209085 cites W2041974941 @default.
• W2017209085 cites W2043856037 @default.
• W2017209085 cites W2050707975 @default.
• W2017209085 cites W2056351034 @default.
• W2017209085 cites W2056859114 @default.
• W2017209085 cites W2064329226 @default.
• W2017209085 cites W2070629019 @default.
• W2017209085 cites W2076407459 @default.
• W2017209085 cites W2079000778 @default.
• W2017209085 cites W2079336414 @default.
• W2017209085 cites W2080674250 @default.
• W2017209085 cites W2084916103 @default.
• W2017209085 cites W2087372329 @default.
• W2017209085 cites W2091601326 @default.
• W2017209085 cites W2102156468 @default.
• W2017209085 cites W2103858336 @default.
• W2017209085 cites W2104439753 @default.
• W2017209085 cites W2108617074 @default.
• W2017209085 cites W2117623357 @default.
• W2017209085 cites W2119308919 @default.
• W2017209085 cites W2128321311 @default.
• W2017209085 cites W2134453100 @default.
• W2017209085 cites W2139144899 @default.
• W2017209085 cites W2139458081 @default.
• W2017209085 cites W2141672711 @default.
• W2017209085 cites W2151246171 @default.
• W2017209085 cites W2463758872 @default.
• W2017209085 doi "https://doi.org/10.1002/eji.1830271115" @default.
• W2017209085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9394808" @default.
• W2017209085 hasPublicationYear "1997" @default.
• W2017209085 type Work @default.
• W2017209085 sameAs 2017209085 @default.
• W2017209085 citedByCount "102" @default.
• W2017209085 countsByYear W20172090852012 @default.
• W2017209085 countsByYear W20172090852013 @default.
• W2017209085 countsByYear W20172090852014 @default.
• W2017209085 countsByYear W20172090852017 @default.
• W2017209085 countsByYear W20172090852019 @default.
• W2017209085 countsByYear W20172090852021 @default.
• W2017209085 countsByYear W20172090852022 @default.
• W2017209085 crossrefType "journal-article" @default.
• W2017209085 hasAuthorship W2017209085A5054164188 @default.
• W2017209085 hasAuthorship W2017209085A5055253279 @default.
• W2017209085 hasBestOaLocation W20172090851 @default.
• W2017209085 hasConcept C134018914 @default.
• W2017209085 hasConcept C191732599 @default.
• W2017209085 hasConcept C203014093 @default.
• W2017209085 hasConcept C2776090121 @default.
• W2017209085 hasConcept C2776914184 @default.
• W2017209085 hasConcept C2777899865 @default.
• W2017209085 hasConcept C2778486448 @default.
• W2017209085 hasConcept C2778609137 @default.
• W2017209085 hasConcept C2778690821 @default.
• W2017209085 hasConcept C2779830541 @default.
• W2017209085 hasConcept C2780640218 @default.
• W2017209085 hasConcept C2780841837 @default.
• W2017209085 hasConcept C2780876595 @default.
• W2017209085 hasConcept C529278444 @default.
• W2017209085 hasConcept C67662055 @default.
• W2017209085 hasConcept C86803240 @default.
• W2017209085 hasConcept C8891405 @default.
• W2017209085 hasConceptScore W2017209085C134018914 @default.
• W2017209085 hasConceptScore W2017209085C191732599 @default.
• W2017209085 hasConceptScore W2017209085C203014093 @default.
• W2017209085 hasConceptScore W2017209085C2776090121 @default.
• W2017209085 hasConceptScore W2017209085C2776914184 @default.
• W2017209085 hasConceptScore W2017209085C2777899865 @default.
• W2017209085 hasConceptScore W2017209085C2778486448 @default.
• W2017209085 hasConceptScore W2017209085C2778609137 @default.
• W2017209085 hasConceptScore W2017209085C2778690821 @default.
• W2017209085 hasConceptScore W2017209085C2779830541 @default.
• W2017209085 hasConceptScore W2017209085C2780640218 @default.
• W2017209085 hasConceptScore W2017209085C2780841837 @default.

• next