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- W2017216400 abstract "Maternal milk is a complex fluid, with multifunctional roles within the developing gastrointestinal tract. Epidermal growth factor (EGF) and heparin-binding EGF-like growth factor (HB-EGF) are members of the family of EGF-related peptides. Biological actions of these growth factors are mediated via interaction with the EGF-receptor (EGF-R). In the early postnatal period, breast milk is the major source of EGF for the developing intestinal mucosa. HB-EGF is also detected in breast milk, but in concentrations 2 to 3 times lower than EGF. With normal physiological conditions, the intestinal epithelium undergoes a continuing process of cell proliferation, differentiation, and maturation. EGF plays an important role in these processes. In pathophysiologic situations, EGF contributes to epithelial protection from injury and post-injury mucosal repair. Necrotizing enterocolitis (NEC) is a devastating disease affecting infants born prematurely. The pathogenesis of NEC is not known, and there is no effective treatment for this disease. In an experimental NEC model, oral administration of a physiological dose of EGF significantly reduces the incidence and severity of NEC. HB-EGF provides similar protection against NEC, but only when pharmacological doses are used. Further studies are necessary before EGF can be introduced as an efficient therapeutic approach of intestinal injury." @default.
- W2017216400 created "2016-06-24" @default.
- W2017216400 creator A5062489944 @default.
- W2017216400 date "2010-02-01" @default.
- W2017216400 modified "2023-09-30" @default.
- W2017216400 title "Milk Epidermal Growth Factor and Gut Protection" @default.
- W2017216400 cites W1501383613 @default.
- W2017216400 cites W1950514687 @default.
- W2017216400 cites W1964493811 @default.
- W2017216400 cites W1965150594 @default.
- W2017216400 cites W1967789917 @default.
- W2017216400 cites W1973491865 @default.
- W2017216400 cites W1977527748 @default.
- W2017216400 cites W1979224484 @default.
- W2017216400 cites W1985644541 @default.
- W2017216400 cites W1989106176 @default.
- W2017216400 cites W1989385434 @default.
- W2017216400 cites W1989427591 @default.
- W2017216400 cites W1989825777 @default.
- W2017216400 cites W1993401546 @default.
- W2017216400 cites W1994745596 @default.
- W2017216400 cites W1994889608 @default.
- W2017216400 cites W1996562091 @default.
- W2017216400 cites W2010268287 @default.
- W2017216400 cites W2010278000 @default.
- W2017216400 cites W2010373786 @default.
- W2017216400 cites W2011642803 @default.
- W2017216400 cites W2011721064 @default.
- W2017216400 cites W2011850551 @default.
- W2017216400 cites W2018153405 @default.
- W2017216400 cites W2019141607 @default.
- W2017216400 cites W2022406746 @default.
- W2017216400 cites W2023950153 @default.
- W2017216400 cites W2036323672 @default.
- W2017216400 cites W203753702 @default.
- W2017216400 cites W2038086562 @default.
- W2017216400 cites W2045585523 @default.
- W2017216400 cites W2048232587 @default.
- W2017216400 cites W2048455231 @default.
- W2017216400 cites W2049073615 @default.
- W2017216400 cites W2049832377 @default.
- W2017216400 cites W2049925143 @default.
- W2017216400 cites W2051326485 @default.
- W2017216400 cites W2053710647 @default.
- W2017216400 cites W2057580190 @default.
- W2017216400 cites W2059270894 @default.
- W2017216400 cites W2063897043 @default.
- W2017216400 cites W2075652947 @default.
- W2017216400 cites W2078261352 @default.
- W2017216400 cites W2079349879 @default.
- W2017216400 cites W2085045473 @default.
- W2017216400 cites W2093970825 @default.
- W2017216400 cites W2094703210 @default.
- W2017216400 cites W2096579470 @default.
- W2017216400 cites W2100818019 @default.
- W2017216400 cites W2107368183 @default.
- W2017216400 cites W2109015418 @default.
- W2017216400 cites W2110706037 @default.
- W2017216400 cites W2113349650 @default.
- W2017216400 cites W2120805579 @default.
- W2017216400 cites W2123451327 @default.
- W2017216400 cites W2126283900 @default.
- W2017216400 cites W2127323107 @default.
- W2017216400 cites W2138230630 @default.
- W2017216400 cites W2139916512 @default.
- W2017216400 cites W2146026954 @default.
- W2017216400 cites W2147488748 @default.
- W2017216400 cites W2149011651 @default.
- W2017216400 cites W2157745003 @default.
- W2017216400 cites W2160555185 @default.
- W2017216400 cites W2163194273 @default.
- W2017216400 cites W2166609912 @default.
- W2017216400 cites W2168741394 @default.
- W2017216400 cites W2169039337 @default.
- W2017216400 cites W2216607261 @default.
- W2017216400 cites W2316868546 @default.
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- W2017216400 doi "https://doi.org/10.1016/j.jpeds.2009.11.018" @default.
- W2017216400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2852639" @default.
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