Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017222771> ?p ?o ?g. }
- W2017222771 endingPage "221" @default.
- W2017222771 startingPage "214" @default.
- W2017222771 abstract "The role played by Met-enkephalin (ME) in epileptic seizures was investigated, using 57 ME kindled rats and 10 saline injected control rats. Repeated microinjection of 10 micrograms ME into the right amygdala (AM) of male Wistar rats led to development of generalized convulsions. One week after the completion of ME kindling, 1 or 2 electrical stimulations (200-400 microA, 60 Hz, 1 sec) of the right AM of ME kindled rats resulted in generalized convulsions in 5 rats. The duration of after-discharge (AD) in the first generalized convulsion induced by electrical AM stimulation in the ME kindled rats was significantly longer than that in the first generalized convulsion induced by electrical stimulation in the saline treated control rats (P less than 0.05). One week after the completion of ME kindling, naloxone (10 or 20 mg/kg, i.p.) given 10 min before the infusion of ME into the other 3 ME kindled rats attenuated both convulsive behavior and electrographical seizures. With the progress of convulsive behavior, the frequency of wet-dog shakes (WDS) tended to decrease and was significantly lower after ME injection in the first stage 5 seizures than after the first ME injection (P less than 0.01). These results strongly suggest that ME has a potent epileptogenic effect on the rat brain which is caused by the opioid receptors. There are some differences between chemical kindling with ME and electrical kindling as indicated by the development of the AD duration and the WDS frequency." @default.
- W2017222771 created "2016-06-24" @default.
- W2017222771 creator A5027344801 @default.
- W2017222771 creator A5028913443 @default.
- W2017222771 creator A5040366576 @default.
- W2017222771 creator A5090571081 @default.
- W2017222771 date "1989-05-01" @default.
- W2017222771 modified "2023-09-25" @default.
- W2017222771 title "Chemical kindling with Met-enkephalin and transfer between chemical and electrical kindling" @default.
- W2017222771 cites W1498891976 @default.
- W2017222771 cites W1967025712 @default.
- W2017222771 cites W1990684080 @default.
- W2017222771 cites W2010051841 @default.
- W2017222771 cites W2011668890 @default.
- W2017222771 cites W2012288345 @default.
- W2017222771 cites W2013606416 @default.
- W2017222771 cites W2030650623 @default.
- W2017222771 cites W2035767489 @default.
- W2017222771 cites W2039183571 @default.
- W2017222771 cites W2047625012 @default.
- W2017222771 cites W2052581573 @default.
- W2017222771 cites W2053996061 @default.
- W2017222771 cites W2056150879 @default.
- W2017222771 cites W2064447763 @default.
- W2017222771 cites W2067366123 @default.
- W2017222771 cites W2067965765 @default.
- W2017222771 cites W2073445795 @default.
- W2017222771 cites W2080734954 @default.
- W2017222771 cites W2083111940 @default.
- W2017222771 cites W2084267389 @default.
- W2017222771 cites W2088353732 @default.
- W2017222771 cites W2090204265 @default.
- W2017222771 cites W2091250890 @default.
- W2017222771 cites W2094787900 @default.
- W2017222771 cites W2103946141 @default.
- W2017222771 cites W2262995109 @default.
- W2017222771 cites W2311442063 @default.
- W2017222771 cites W2413994414 @default.
- W2017222771 cites W2416901007 @default.
- W2017222771 doi "https://doi.org/10.1016/0920-1211(89)90026-0" @default.
- W2017222771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2543558" @default.
- W2017222771 hasPublicationYear "1989" @default.
- W2017222771 type Work @default.
- W2017222771 sameAs 2017222771 @default.
- W2017222771 citedByCount "8" @default.
- W2017222771 countsByYear W20172227712014 @default.
- W2017222771 countsByYear W20172227712015 @default.
- W2017222771 crossrefType "journal-article" @default.
- W2017222771 hasAuthorship W2017222771A5027344801 @default.
- W2017222771 hasAuthorship W2017222771A5028913443 @default.
- W2017222771 hasAuthorship W2017222771A5040366576 @default.
- W2017222771 hasAuthorship W2017222771A5090571081 @default.
- W2017222771 hasConcept C100691959 @default.
- W2017222771 hasConcept C126322002 @default.
- W2017222771 hasConcept C134018914 @default.
- W2017222771 hasConcept C15744967 @default.
- W2017222771 hasConcept C169760540 @default.
- W2017222771 hasConcept C170493617 @default.
- W2017222771 hasConcept C185592680 @default.
- W2017222771 hasConcept C24998067 @default.
- W2017222771 hasConcept C2777010014 @default.
- W2017222771 hasConcept C2777397205 @default.
- W2017222771 hasConcept C2777803847 @default.
- W2017222771 hasConcept C2778186239 @default.
- W2017222771 hasConcept C2778750930 @default.
- W2017222771 hasConcept C2779144063 @default.
- W2017222771 hasConcept C2781063702 @default.
- W2017222771 hasConcept C42219234 @default.
- W2017222771 hasConcept C71924100 @default.
- W2017222771 hasConceptScore W2017222771C100691959 @default.
- W2017222771 hasConceptScore W2017222771C126322002 @default.
- W2017222771 hasConceptScore W2017222771C134018914 @default.
- W2017222771 hasConceptScore W2017222771C15744967 @default.
- W2017222771 hasConceptScore W2017222771C169760540 @default.
- W2017222771 hasConceptScore W2017222771C170493617 @default.
- W2017222771 hasConceptScore W2017222771C185592680 @default.
- W2017222771 hasConceptScore W2017222771C24998067 @default.
- W2017222771 hasConceptScore W2017222771C2777010014 @default.
- W2017222771 hasConceptScore W2017222771C2777397205 @default.
- W2017222771 hasConceptScore W2017222771C2777803847 @default.
- W2017222771 hasConceptScore W2017222771C2778186239 @default.
- W2017222771 hasConceptScore W2017222771C2778750930 @default.
- W2017222771 hasConceptScore W2017222771C2779144063 @default.
- W2017222771 hasConceptScore W2017222771C2781063702 @default.
- W2017222771 hasConceptScore W2017222771C42219234 @default.
- W2017222771 hasConceptScore W2017222771C71924100 @default.
- W2017222771 hasIssue "3" @default.
- W2017222771 hasLocation W20172227711 @default.
- W2017222771 hasLocation W20172227712 @default.
- W2017222771 hasOpenAccess W2017222771 @default.
- W2017222771 hasPrimaryLocation W20172227711 @default.
- W2017222771 hasRelatedWork W1971873722 @default.
- W2017222771 hasRelatedWork W1983900786 @default.
- W2017222771 hasRelatedWork W1988120818 @default.
- W2017222771 hasRelatedWork W2003374522 @default.
- W2017222771 hasRelatedWork W2003704365 @default.
- W2017222771 hasRelatedWork W2027200927 @default.
- W2017222771 hasRelatedWork W2048777941 @default.