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• W2017227150 abstract "The development of a brain abscess due to Nocardia asteroides is described in a patient during therapy with ampicillin and either sulfadiazine or sulfisoxazole for pulmonary nocardiosis. Although the pulmonary nocardiosis responded to these antimicrobial agents, eradication of the cerebral nocardiosis required both surgical excision of the abscess and a 3 month course of trimethoprim (TMP)-sulfamethoxazole (SMX). It is speculated that the poor response of the cerebral infection to ampicillin and sulfisoxazole was related to their poor penetration into the cerebrospinal fluid. Four hours after both a 1 g intravenous dose of ampicillin and a 3 g oral dose of sulfisoxazole, there was no detectable activity of these drugs in the cerebrospinal fluid, despite adequate concentrations in the blood. On the other hand, 6 hours after a 160 mg oral dose of TMP, a level of 5.1 μg/g was detected in infected brain tissue. Synergistic activity between TMP and SMX was demonstrated: the minimum inhibitory concentration of TMP alone for the patient's organism was greater than 5 μg/ml; of SMX alone, 24.5 μg/ml; for a 1:4 combination of TMP/SMX, 1.5 and 6.0 μg/ml, respectively; and for a 1:20 combination of TMP/ SMX, 0.5 and 9.5 μg/ml, respectively." @default.
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• W2017227150 date "1974-10-01" @default.
• W2017227150 modified "2023-10-17" @default.
• W2017227150 title "Treatment of nocardial infection with trimethoprim and sulfamethoxazole" @default.
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• W2017227150 doi "https://doi.org/10.1016/0002-9343(74)90022-9" @default.
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