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• W2017227695 abstract "The long-acting antirheumatic drug D-penicillamine was found to inhibit the growth of asynchronous cultures of rabbit articular chondrocytes. This inhibitory effect was dose-related between 5 X 10(-4) M and 5 X 10(-3) M and was time-dependent for a given dose. Flow cytometric analysis showed that drug exposure led to a slowdown in cell cycle progression. This was manifested as a decrease in the number of cells in S phase, due especially to an accumulation of cells in G0 G1 and also to a slight cessation of cell transit through G2 M. Recovery experiments showed that the effect is transitory and reversible. It is suggested that the articular chondrocyte is a target cell for D-penicillamine and that these cells have a D-penicillamine sensitive restriction point in the G0 G1 phase of the cell cycle and to a less extent in the G2 M phase." @default.
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• W2017227695 date "1984-04-01" @default.
• W2017227695 modified "2023-09-27" @default.
• W2017227695 title "Effects of D-penicillamine on growth and cell cycle kinetics of cultured rabbit articular chondrocytes." @default.
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• W2017227695 doi "https://doi.org/10.1136/ard.43.2.333" @default.
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