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• W2017230913 abstract "Thyrotropic tumors (TtT97) contain mRNA transcripts for three T3-receptor (TR) isoforms, α1, β 1 and β2, and a non-receptor α2-variant. We administered T4 (5 mg/l of drinking water) for one month to TtT97-bearing mice, to examine its effect on tumor growth and tumor TR isoform steady-state mRNA levels. Baseline mice were killed at the start of the experiment, and placebo mice were maintained hypothyroid. The treated tumors were 30–35% smaller than the baseline tumors (p = NS), while the placebo tumors were 2- to 7-fold larger than the baseline tumors (p < 0.05). TRβ1 mRNA increased 5- to 6-fold, while TRβ2 mRNA decreased by 76%. TRα1 and the α2-variant decreased by 52% and 70%, respectively. Therefore, the tumors decreased their growth rate in response to T4 administration, and increased the ratio of TRβ1 to TRβ2 mRNA. This raises the intriguing possibility of a correlation between the relative abundance of the TRβ isoforms and tumor growth." @default.
• W2017230913 created "2016-06-24" @default.
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• W2017230913 date "1993-02-01" @default.
• W2017230913 modified "2023-09-24" @default.
• W2017230913 title "Effect of thyroid hormone on T3-receptor mRNA levels and growth of thyrotropic tumors" @default.
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• W2017230913 doi "https://doi.org/10.1016/0303-7207(93)90257-k" @default.
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