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- W2017231834 abstract "1. Fluid secretion was induced in the jejunum of anesthetised rats using vasoactive intestinal peptide. 2. The adenosine antagonist, DPCPX (0.1 mg/kg), suppressed the antisecretory action of morphine (10 mg/kg), but naloxone (80 micrograms/kg) did not inhibit the antisecretory response of the adenosine agonist, NECA (40 micrograms/kg), at a dose previously shown to antagonize the antisecretory response of morphine. 3. NECA (40 (micrograms/kg) reversed secretion in pithed and reserpine-pretreated (5 mg/kg subcutaneously) rats. 4. It is proposed that adenosine acts as a mediator of the morphine antisecretory effect at a site distal to the noradrenergic neurons involved in the action of morphine." @default.
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- W2017231834 date "1997-05-01" @default.
- W2017231834 modified "2023-10-18" @default.
- W2017231834 title "Studies investigating the possible involvement of adenosine in the antisecretory action of morphine" @default.
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- W2017231834 doi "https://doi.org/10.1016/s0306-3623(96)00358-8" @default.
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