Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017235610> ?p ?o ?g. }
- W2017235610 endingPage "25" @default.
- W2017235610 startingPage "17" @default.
- W2017235610 abstract "Peptides containing l-Nε-acetyl-lysine (l-AcK) or its side chain modified analogs were prepared and assayed using SIRT1, the prototypical human silent information regulator 2 (Sir2) enzyme. While previous studies showed that the side chain acetyl group of l-AcK can be extended to bulkier acyl groups for Sir2 (including SIRT1)-catalyzed lysine Nε-deacylation reaction, our current study suggested that SIRT1-catalyzed deacetylation reaction had a very stringent requirement for the distance between the α-carbon and the side chain acetamido group, with that found in l-AcK being optimal. Moreover, our current study showed that SIRT1 catalyzed the stereospecific deacetylation of l-AcK versus its d-isomer. The results from our current study shall constitute another piece of important information to be considered when designing inhibitors for SIRT1 and Sir2 enzymes in general." @default.
- W2017235610 created "2016-06-24" @default.
- W2017235610 creator A5034899868 @default.
- W2017235610 creator A5047986021 @default.
- W2017235610 creator A5063837700 @default.
- W2017235610 creator A5081500087 @default.
- W2017235610 date "2010-02-01" @default.
- W2017235610 modified "2023-10-18" @default.
- W2017235610 title "Substrate specificity of SIRT1-catalyzed lysine Nε-deacetylation reaction probed with the side chain modified Nε-acetyl-lysine analogs" @default.
- W2017235610 cites W1518071796 @default.
- W2017235610 cites W1969458750 @default.
- W2017235610 cites W1972008563 @default.
- W2017235610 cites W1976596063 @default.
- W2017235610 cites W1982040190 @default.
- W2017235610 cites W1983094204 @default.
- W2017235610 cites W1995042750 @default.
- W2017235610 cites W1996395636 @default.
- W2017235610 cites W1998932317 @default.
- W2017235610 cites W2001346869 @default.
- W2017235610 cites W2005789183 @default.
- W2017235610 cites W2012183441 @default.
- W2017235610 cites W2018161655 @default.
- W2017235610 cites W2019627057 @default.
- W2017235610 cites W2026029935 @default.
- W2017235610 cites W2032991279 @default.
- W2017235610 cites W2034191525 @default.
- W2017235610 cites W2043932983 @default.
- W2017235610 cites W2044784487 @default.
- W2017235610 cites W2054447845 @default.
- W2017235610 cites W2060995176 @default.
- W2017235610 cites W2064352591 @default.
- W2017235610 cites W2072526811 @default.
- W2017235610 cites W2075227441 @default.
- W2017235610 cites W2081685122 @default.
- W2017235610 cites W2083411624 @default.
- W2017235610 cites W2086102706 @default.
- W2017235610 cites W2090381051 @default.
- W2017235610 cites W2092160215 @default.
- W2017235610 cites W2111184587 @default.
- W2017235610 cites W2112351720 @default.
- W2017235610 cites W2121431024 @default.
- W2017235610 cites W2123927456 @default.
- W2017235610 cites W2124595934 @default.
- W2017235610 cites W2128224063 @default.
- W2017235610 cites W2134629557 @default.
- W2017235610 cites W2135243105 @default.
- W2017235610 cites W2152390180 @default.
- W2017235610 cites W2153704476 @default.
- W2017235610 cites W2165589777 @default.
- W2017235610 cites W2165894498 @default.
- W2017235610 cites W2171497447 @default.
- W2017235610 cites W4322701602 @default.
- W2017235610 doi "https://doi.org/10.1016/j.bioorg.2009.10.001" @default.
- W2017235610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19914676" @default.
- W2017235610 hasPublicationYear "2010" @default.
- W2017235610 type Work @default.
- W2017235610 sameAs 2017235610 @default.
- W2017235610 citedByCount "30" @default.
- W2017235610 countsByYear W20172356102012 @default.
- W2017235610 countsByYear W20172356102013 @default.
- W2017235610 countsByYear W20172356102014 @default.
- W2017235610 countsByYear W20172356102015 @default.
- W2017235610 countsByYear W20172356102016 @default.
- W2017235610 countsByYear W20172356102017 @default.
- W2017235610 countsByYear W20172356102018 @default.
- W2017235610 countsByYear W20172356102019 @default.
- W2017235610 countsByYear W20172356102020 @default.
- W2017235610 countsByYear W20172356102021 @default.
- W2017235610 countsByYear W20172356102022 @default.
- W2017235610 countsByYear W20172356102023 @default.
- W2017235610 crossrefType "journal-article" @default.
- W2017235610 hasAuthorship W2017235610A5034899868 @default.
- W2017235610 hasAuthorship W2017235610A5047986021 @default.
- W2017235610 hasAuthorship W2017235610A5063837700 @default.
- W2017235610 hasAuthorship W2017235610A5081500087 @default.
- W2017235610 hasConcept C104317684 @default.
- W2017235610 hasConcept C111368507 @default.
- W2017235610 hasConcept C119157956 @default.
- W2017235610 hasConcept C127313418 @default.
- W2017235610 hasConcept C161790260 @default.
- W2017235610 hasConcept C178790620 @default.
- W2017235610 hasConcept C181199279 @default.
- W2017235610 hasConcept C185592680 @default.
- W2017235610 hasConcept C187921627 @default.
- W2017235610 hasConcept C204921945 @default.
- W2017235610 hasConcept C2776016237 @default.
- W2017235610 hasConcept C2777289219 @default.
- W2017235610 hasConcept C515207424 @default.
- W2017235610 hasConcept C521977710 @default.
- W2017235610 hasConcept C55493867 @default.
- W2017235610 hasConcept C71240020 @default.
- W2017235610 hasConceptScore W2017235610C104317684 @default.
- W2017235610 hasConceptScore W2017235610C111368507 @default.
- W2017235610 hasConceptScore W2017235610C119157956 @default.
- W2017235610 hasConceptScore W2017235610C127313418 @default.
- W2017235610 hasConceptScore W2017235610C161790260 @default.
- W2017235610 hasConceptScore W2017235610C178790620 @default.
- W2017235610 hasConceptScore W2017235610C181199279 @default.