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• W2017237517 abstract "The mechanism of signal transduction by steroid receptor proteins is complex and not yet understood. We describe here a facile genetic strategy for dissection of the rat glucocorticoid receptor signaling domain, a region of the protein that binds and transduces the hormonal signal. We found that the characteristics of signal transduction by the receptor expressed in yeast were similar to those of endogenous receptors in mammalian cells. Interestingly, the rank order of particular ligands differed between species with respect to receptor binding and biological efficacy. This suggests that factors in addition to the receptor alone must determine or influence ligand efficacy in vivo. To obtain a collection of receptors with distinct defects in signal transduction, we screened in yeast an extensive series of random point mutations introduced in that region in vitro. Three phenotypic classes were obtained: one group failed to bind hormone, a second displayed altered ligand specificity, and a third bound hormone but lacked regulatory activity. Our results demonstrate that analysis of glucocorticoid receptor action in yeast provides a general approach for analyzing the mechanism of signaling by the nuclear receptor family and may facilitate identification of non-receptor factors that participate in this process." @default.
• W2017237517 created "2016-06-24" @default.
• W2017237517 creator A5009598129 @default.
• W2017237517 creator A5060305478 @default.
• W2017237517 date "1992-11-01" @default.
• W2017237517 modified "2023-09-24" @default.
• W2017237517 title "Genetic dissection of the signaling domain of a mammalian steroid receptor in yeast." @default.
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• W2017237517 doi "https://doi.org/10.1091/mbc.3.11.1245" @default.
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