FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017238521> ?p ?o ?g. }

• W2017238521 abstract "Systemic (1-10 mg/kg, s.c.), intracerebroventricular (i.c.v. 20-80 micrograms) and spinal intrathecal (i.t., 5-20 micrograms) administration of meptazinol hydrochloride produced dose-related inhibition of reflex contractions of the urinary bladder, recorded isometrically in urethane-anesthetized rats. The effects of meptazinol were reversed by naloxone administered by the same route. Indeed, this was achieved with intracerebroventricular or intrathecal administration of naloxone (2 micrograms), which also selectively antagonized the mu-receptor ligand [D-Ala2, MePhe4, Gly(ol)5]enkephalin (DAGO). However ICI 174,864 (3 micrograms, i.c.v. or i.t.), a delta-opioid receptor antagonist, did not affect the actions of meptazinol given intracerebroventricularly or intrathecally though it consistently abolished the equieffective actions of a selective delta-receptor ligand (2-D-penicillamine, 5-L-penicillamine) enkephalin (DPLPE). Naloxonazine (5 micrograms, i.c.v. or i.t.), an irreversible mu 1-opioid receptor antagonist, produced prolonged antagonism of the effects of DPLPE and meptazinol. The effects of DPLPE partially or completely recovered by 24 hr, indicating that naloxonazine produced prolonged antagonism of delta-opioid receptors. The effects of maptazinol however only recovered after 72 hr, suggesting that antagonism by naloxonazine of this ligand was irreversible and was mediated through a unique opioid receptor interaction. Subthreshold doses of meptazinol (10 micrograms, i.c.v.; 3 micrograms, i.t.) consistently antagonized the effects of morphine given intracerebroventricularly or intrathecally but not the equieffective doses of DPLPE or DAGO. These observations suggest that meptazinol inhibited reflex contractions of the bladder by supraspinal and spinal mu-opioid receptor activation. Furthermore, its agonistic effect and its antagonistic actions were compatible with interactions at a subpopulation of opioid receptors, possibly mu 1-receptors.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2017238521 created "2016-06-24" @default.
• W2017238521 creator A5010960430 @default.
• W2017238521 creator A5074811700 @default.
• W2017238521 creator A5077902095 @default.
• W2017238521 date "1986-04-01" @default.
• W2017238521 modified "2023-09-25" @default.
• W2017238521 title "Meptazinol: Unusual in vivo opioid receptor activity at supraspinal and spinal sites" @default.
• W2017238521 cites W1491994386 @default.
• W2017238521 cites W1620458381 @default.
• W2017238521 cites W1748088453 @default.
• W2017238521 cites W1789439462 @default.
• W2017238521 cites W1900414416 @default.
• W2017238521 cites W1964131185 @default.
• W2017238521 cites W1968412702 @default.
• W2017238521 cites W1974427860 @default.
• W2017238521 cites W1975327942 @default.
• W2017238521 cites W1977055516 @default.
• W2017238521 cites W1978593108 @default.
• W2017238521 cites W1997338758 @default.
• W2017238521 cites W1998504694 @default.
• W2017238521 cites W2013907129 @default.
• W2017238521 cites W2016275972 @default.
• W2017238521 cites W2017208092 @default.
• W2017238521 cites W2022583434 @default.
• W2017238521 cites W2023021788 @default.
• W2017238521 cites W2025590322 @default.
• W2017238521 cites W2027814626 @default.
• W2017238521 cites W2030787536 @default.
• W2017238521 cites W2032220787 @default.
• W2017238521 cites W2032238533 @default.
• W2017238521 cites W2043040755 @default.
• W2017238521 cites W2047865327 @default.
• W2017238521 cites W2056829831 @default.
• W2017238521 cites W2072195217 @default.
• W2017238521 cites W2074454823 @default.
• W2017238521 cites W2075811628 @default.
• W2017238521 cites W2080508768 @default.
• W2017238521 cites W2089315019 @default.
• W2017238521 cites W2102312379 @default.
• W2017238521 cites W2102620584 @default.
• W2017238521 cites W2133382298 @default.
• W2017238521 cites W2171181544 @default.
• W2017238521 cites W2397360999 @default.
• W2017238521 cites W2407212282 @default.
• W2017238521 doi "https://doi.org/10.1016/0028-3908(86)90228-5" @default.
• W2017238521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3012396" @default.
• W2017238521 hasPublicationYear "1986" @default.
• W2017238521 type Work @default.
• W2017238521 sameAs 2017238521 @default.
• W2017238521 citedByCount "10" @default.
• W2017238521 crossrefType "journal-article" @default.
• W2017238521 hasAuthorship W2017238521A5010960430 @default.
• W2017238521 hasAuthorship W2017238521A5074811700 @default.
• W2017238521 hasAuthorship W2017238521A5077902095 @default.
• W2017238521 hasConcept C126322002 @default.
• W2017238521 hasConcept C134018914 @default.
• W2017238521 hasConcept C14397066 @default.
• W2017238521 hasConcept C170493617 @default.
• W2017238521 hasConcept C185592680 @default.
• W2017238521 hasConcept C2776885963 @default.
• W2017238521 hasConcept C2777383412 @default.
• W2017238521 hasConcept C2777389121 @default.
• W2017238521 hasConcept C2777803847 @default.
• W2017238521 hasConcept C2778122271 @default.
• W2017238521 hasConcept C2778750930 @default.
• W2017238521 hasConcept C2779886867 @default.
• W2017238521 hasConcept C2781063702 @default.
• W2017238521 hasConcept C71924100 @default.
• W2017238521 hasConcept C98274493 @default.
• W2017238521 hasConceptScore W2017238521C126322002 @default.
• W2017238521 hasConceptScore W2017238521C134018914 @default.
• W2017238521 hasConceptScore W2017238521C14397066 @default.
• W2017238521 hasConceptScore W2017238521C170493617 @default.
• W2017238521 hasConceptScore W2017238521C185592680 @default.
• W2017238521 hasConceptScore W2017238521C2776885963 @default.
• W2017238521 hasConceptScore W2017238521C2777383412 @default.
• W2017238521 hasConceptScore W2017238521C2777389121 @default.
• W2017238521 hasConceptScore W2017238521C2777803847 @default.
• W2017238521 hasConceptScore W2017238521C2778122271 @default.
• W2017238521 hasConceptScore W2017238521C2778750930 @default.
• W2017238521 hasConceptScore W2017238521C2779886867 @default.
• W2017238521 hasConceptScore W2017238521C2781063702 @default.
• W2017238521 hasConceptScore W2017238521C71924100 @default.
• W2017238521 hasConceptScore W2017238521C98274493 @default.
• W2017238521 hasLocation W20172385211 @default.
• W2017238521 hasLocation W20172385212 @default.
• W2017238521 hasOpenAccess W2017238521 @default.
• W2017238521 hasPrimaryLocation W20172385211 @default.
• W2017238521 hasRelatedWork W127097545 @default.
• W2017238521 hasRelatedWork W1965579710 @default.
• W2017238521 hasRelatedWork W1985649660 @default.
• W2017238521 hasRelatedWork W2013581064 @default.
• W2017238521 hasRelatedWork W2020502640 @default.
• W2017238521 hasRelatedWork W2022703311 @default.
• W2017238521 hasRelatedWork W2032150540 @default.
• W2017238521 hasRelatedWork W2067032885 @default.
• W2017238521 hasRelatedWork W2125973528 @default.
• W2017238521 hasRelatedWork W86576500 @default.
• W2017238521 isParatext "false" @default.

• next