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• W2017238965 abstract "Protein kinase C (PKC) is required for transcriptional induction of 2′–5′-oligoadenylate (2–5A) synthetases by interferon (IFN)-α. Regulatory elements located in the 5′-flanking region of the p69 2–5A synthetase gene have been identified which are required for transcriptional stimulation by PKC. The region from −366 to −117 bp, relative to the translational start site, contains three sequence motifs that resemble interferon stimulated response elements/interferon regulatory factor elements (ISRE/IRF-E), which are required for stimulation of the IFN-α-response by the PKC activator, 12-O-tetradecanoyl phorbol-13-acetate (TPA). Constructs which have a deletion of the region containing IRF-Es located at −361 bp to −280 and at −246 to −172 bp do not respond to TPA treatment. Likewise, introduction of point mutations into either of these IRF-Es decreases stimulation of IFN-α induction by TPA and constructs containing point mutations in both upstream IRF-Es are non-responsive to TPA. Binding of the inducible factor to the ISRE is abrogated in cells depleted of PKC by prolonged treatment with TPA. PKC appears to function as a signaling component in an IFN-independent pathway that increases the activity of IFN-α- regulated transcription factors in the nucleus." @default.
• W2017238965 created "2016-06-24" @default.
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• W2017238965 date "1999-09-01" @default.
• W2017238965 modified "2023-10-16" @default.
• W2017238965 title "Transcriptional induction of p69 2′–5′-oligoadenylate synthetase by interferon-α is stimulated by 12-O-tetradecanoyl phorbol-13-acetate through IRF/ISRE binding motifs" @default.
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• W2017238965 doi "https://doi.org/10.1016/s0378-1119(99)00284-x" @default.
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