FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017240214> ?p ?o ?g. }

• W2017240214 endingPage "477" @default.
• W2017240214 startingPage "471" @default.
• W2017240214 abstract "Using 125I-labeled neurotensin (NT), chicken liver was found to contain high affinity, G-protein-linked receptors directed specifically towards the bioactive C-terminal portion of NT. Binding was proportional to membrane and optimal at pH 7.5. The apparent Kd (approximately 91 pM) for this single class of binding sites was similar to Kds reported for the high-affinity components of NT binding to mammalian brain and intestinal membranes. However, the binding capacity (Bmax, approximately 2.3 pmol/mg) was 10-100 times higher than values reported for these mammalian tissues. Binding was inhibited by GTP analogues and by treatment with pertussis toxin but not by cholera toxin. Treatments with alkaline solutions, shown to inactivate G-proteins, decreased subsequent binding at pH 7.5. Whereas low concentrations of Mg2+ (optimum, approximately 0.5 mM) enhanced NT binding, concentrations of 5 mM and above were inhibitory. Cross-linking of 125I-labeled NT to liver membranes using glutaraldehyde specifically labeled two substances of approximately 52 and approximately 90 kDa, which could represent different binding proteins or complexes. These data demonstrate the presence in chicken liver of large amounts of high-affinity NT receptor(s) coupled to pertussis toxin-sensitive G-protein(s)." @default.
• W2017240214 created "2016-06-24" @default.
• W2017240214 creator A5015979266 @default.
• W2017240214 creator A5082029120 @default.
• W2017240214 date "1995-01-01" @default.
• W2017240214 modified "2023-10-02" @default.
• W2017240214 title "Chicken liver contains a large quantity of a G-protein-linked neurotensin receptor" @default.
• W2017240214 cites W1485697636 @default.
• W2017240214 cites W1508891961 @default.
• W2017240214 cites W1512173400 @default.
• W2017240214 cites W1518910188 @default.
• W2017240214 cites W1570939625 @default.
• W2017240214 cites W1573974844 @default.
• W2017240214 cites W1607957872 @default.
• W2017240214 cites W1951908100 @default.
• W2017240214 cites W1969574390 @default.
• W2017240214 cites W1974739900 @default.
• W2017240214 cites W1978427859 @default.
• W2017240214 cites W1988006399 @default.
• W2017240214 cites W1993593811 @default.
• W2017240214 cites W2002935418 @default.
• W2017240214 cites W2018723879 @default.
• W2017240214 cites W2036375936 @default.
• W2017240214 cites W2043218136 @default.
• W2017240214 cites W2055431171 @default.
• W2017240214 cites W2061341223 @default.
• W2017240214 cites W2064993556 @default.
• W2017240214 cites W2070020792 @default.
• W2017240214 cites W2070785197 @default.
• W2017240214 cites W2075676530 @default.
• W2017240214 cites W2077730943 @default.
• W2017240214 cites W2083686661 @default.
• W2017240214 cites W2085133815 @default.
• W2017240214 cites W2147505511 @default.
• W2017240214 cites W2218739829 @default.
• W2017240214 doi "https://doi.org/10.1016/0196-9781(94)00215-r" @default.
• W2017240214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7651901" @default.
• W2017240214 hasPublicationYear "1995" @default.
• W2017240214 type Work @default.
• W2017240214 sameAs 2017240214 @default.
• W2017240214 citedByCount "7" @default.
• W2017240214 countsByYear W20172402142013 @default.
• W2017240214 countsByYear W20172402142014 @default.
• W2017240214 countsByYear W20172402142022 @default.
• W2017240214 crossrefType "journal-article" @default.
• W2017240214 hasAuthorship W2017240214A5015979266 @default.
• W2017240214 hasAuthorship W2017240214A5082029120 @default.
• W2017240214 hasConcept C104317684 @default.
• W2017240214 hasConcept C107824862 @default.
• W2017240214 hasConcept C118303440 @default.
• W2017240214 hasConcept C118716 @default.
• W2017240214 hasConcept C134018914 @default.
• W2017240214 hasConcept C153911025 @default.
• W2017240214 hasConcept C170493617 @default.
• W2017240214 hasConcept C181199279 @default.
• W2017240214 hasConcept C185592680 @default.
• W2017240214 hasConcept C2777006276 @default.
• W2017240214 hasConcept C2777367657 @default.
• W2017240214 hasConcept C2778976297 @default.
• W2017240214 hasConcept C2909545319 @default.
• W2017240214 hasConcept C41625074 @default.
• W2017240214 hasConcept C49773422 @default.
• W2017240214 hasConcept C553089730 @default.
• W2017240214 hasConcept C55493867 @default.
• W2017240214 hasConcept C80631254 @default.
• W2017240214 hasConcept C86803240 @default.
• W2017240214 hasConceptScore W2017240214C104317684 @default.
• W2017240214 hasConceptScore W2017240214C107824862 @default.
• W2017240214 hasConceptScore W2017240214C118303440 @default.
• W2017240214 hasConceptScore W2017240214C118716 @default.
• W2017240214 hasConceptScore W2017240214C134018914 @default.
• W2017240214 hasConceptScore W2017240214C153911025 @default.
• W2017240214 hasConceptScore W2017240214C170493617 @default.
• W2017240214 hasConceptScore W2017240214C181199279 @default.
• W2017240214 hasConceptScore W2017240214C185592680 @default.
• W2017240214 hasConceptScore W2017240214C2777006276 @default.
• W2017240214 hasConceptScore W2017240214C2777367657 @default.
• W2017240214 hasConceptScore W2017240214C2778976297 @default.
• W2017240214 hasConceptScore W2017240214C2909545319 @default.
• W2017240214 hasConceptScore W2017240214C41625074 @default.
• W2017240214 hasConceptScore W2017240214C49773422 @default.
• W2017240214 hasConceptScore W2017240214C553089730 @default.
• W2017240214 hasConceptScore W2017240214C55493867 @default.
• W2017240214 hasConceptScore W2017240214C80631254 @default.
• W2017240214 hasConceptScore W2017240214C86803240 @default.
• W2017240214 hasIssue "3" @default.
• W2017240214 hasLocation W20172402141 @default.
• W2017240214 hasLocation W20172402142 @default.
• W2017240214 hasOpenAccess W2017240214 @default.
• W2017240214 hasPrimaryLocation W20172402141 @default.
• W2017240214 hasRelatedWork W1584041239 @default.
• W2017240214 hasRelatedWork W1968353921 @default.
• W2017240214 hasRelatedWork W2015516878 @default.
• W2017240214 hasRelatedWork W2017240214 @default.
• W2017240214 hasRelatedWork W2031370301 @default.
• W2017240214 hasRelatedWork W2033510149 @default.
• W2017240214 hasRelatedWork W2093958384 @default.
• W2017240214 hasRelatedWork W2254649052 @default.

• next