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- W2017240728 abstract "Vitamin A is known to cause proximodistal duplication of parts of the limb during limb regeneration in amphibians. The objective of this study was to investigate the cellular site of action of vitamin A when it causes this duplication in the axolotl Ambystoma mexicanum. Both forelimbs of larval axolotls were amputated through the radius–ulna, and treated with retinol palmitate by immersion for 10 days. Actinomycin D, cycloheximide, and tunicamycin were each applied to the right forelimb by implantation of a silastin block containing one of these antibiotics on days 2 and 6 postamputation. The left limb received a control silastin block at the same time. Actinomycin D and cycloheximide completely blocked the proximodistal duplication caused by retinol palmitate, and tunicamycin substantially inhibited the development of these duplications. These results suggest that retinol palmitate (i) induces duplication by switching on a gene (as it is antagonized by actinomycin D), (ii) requires protein synthesis (as it is antagonized by cycloheximide), and (iii) may effect glycoprotein synthesis (as it is antagonized by tunicamycin)." @default.
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- W2017240728 date "1988-04-01" @default.
- W2017240728 modified "2023-10-16" @default.
- W2017240728 title "Actinomycin D, cycloheximide, and tunicamycin inhibit vitamin A induced proximodistal duplication during limb regeneration in the axolotl Ambystoma mexicanum" @default.
- W2017240728 doi "https://doi.org/10.1139/z88-130" @default.
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