FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017241872> ?p ?o ?g. }

• W2017241872 endingPage "575" @default.
• W2017241872 startingPage "555" @default.
• W2017241872 abstract "Abstract Lipopolysaccharide (LPS) is the main surface constituent of Gram‐negative bacteria. Lipid A, the hydrophobic moiety, outer monolayer of the outer cell membrane forms the major component of LPS. Immunogenic Lipid A is recognized by the innate immune system through the TLR 4/MD‐2 complex. Pseudomonas aeruginosa PAO1, a Gram‐negative bacterium is known to cause nosocomial infection and known for its adaptation to adverse environmental conditions. Pseudomonas aeruginosa can infect a broad host spectrum including Caenorhabditis elegans , a simple free living soil nematode. Here, we reveal that PAO1 modifies its Lipid A during the host interaction with C. elegans . The penta‐acylated form of Lipid A was identified by using matrix assisted laser desorption ionization–time of flight analysis and the β‐(1,6)‐linked disaccharide of glucosamine with phosphate groups, 2 and 2′ amide linked fatty acid chain and 3 and 3′ ester linked fatty acids were investigated for the modification using the non destructive 1 H NMR, spin–lattice ( T 1 ) relaxation measurement, differential scanning calorimetry. T 1 relaxation measurements showed that the 2 and 2′ amide linked fatty acid chain, –CH in the glucosamine disaccharide of PAO1 lipid A, in an exposed host had a different spin lattice relaxation time compared to an unexposed host and the findings were reconfirmed using in vitro human corneal epithelial cells cell lines. Furthermore, scanning electron microscope and confocal laser scanning microscopy analysis revealed that the P. aeruginosa PAO1 biofilm formation was disturbed in the exposed host condition. The daf ‐ 12 , daf ‐ 16 , tol ‐ 1 , pmk ‐ 1, ins ‐ 7 and ilys 3 immune genes of C. elegans were examined with live bacterial and isolated lipid moiety infection and the expression was found to be highly specific. Overall, the present study revealed that PAO1 modified its 2 and 2′ amide linked fatty acid chain in the lipid A of PAO1 LPS during the exposed host condition." @default.
• W2017241872 created "2016-06-24" @default.
• W2017241872 creator A5046578220 @default.
• W2017241872 creator A5060606567 @default.
• W2017241872 creator A5069223310 @default.
• W2017241872 date "2014-04-11" @default.
• W2017241872 modified "2023-09-26" @default.
• W2017241872 title "Analysis of<i>Pseudomonas aeruginosa</i>PAO1 Lipid A Changes During the Interaction with Model Organism,<i>Caenorhabditis elegans</i>" @default.
• W2017241872 cites W1486595217 @default.
• W2017241872 cites W1490993461 @default.
• W2017241872 cites W1559177698 @default.
• W2017241872 cites W1927962048 @default.
• W2017241872 cites W1966350980 @default.
• W2017241872 cites W1969959057 @default.
• W2017241872 cites W1977787135 @default.
• W2017241872 cites W1988376786 @default.
• W2017241872 cites W2001839140 @default.
• W2017241872 cites W2005031995 @default.
• W2017241872 cites W2012104592 @default.
• W2017241872 cites W2015905438 @default.
• W2017241872 cites W2028915734 @default.
• W2017241872 cites W2031883464 @default.
• W2017241872 cites W2036492728 @default.
• W2017241872 cites W2045316957 @default.
• W2017241872 cites W2051101891 @default.
• W2017241872 cites W2060908989 @default.
• W2017241872 cites W2072652504 @default.
• W2017241872 cites W2076637583 @default.
• W2017241872 cites W2077590888 @default.
• W2017241872 cites W2081267709 @default.
• W2017241872 cites W2083691983 @default.
• W2017241872 cites W2101580369 @default.
• W2017241872 cites W2108213807 @default.
• W2017241872 cites W2117639785 @default.
• W2017241872 cites W2125969054 @default.
• W2017241872 cites W2127934565 @default.
• W2017241872 cites W2138361755 @default.
• W2017241872 cites W2139382674 @default.
• W2017241872 cites W2147246163 @default.
• W2017241872 cites W2147370341 @default.
• W2017241872 cites W2148605910 @default.
• W2017241872 cites W2164237791 @default.
• W2017241872 cites W2167140118 @default.
• W2017241872 cites W2168485847 @default.
• W2017241872 cites W4234317413 @default.
• W2017241872 doi "https://doi.org/10.1007/s11745-014-3898-3" @default.
• W2017241872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24722928" @default.
• W2017241872 hasPublicationYear "2014" @default.
• W2017241872 type Work @default.
• W2017241872 sameAs 2017241872 @default.
• W2017241872 citedByCount "8" @default.
• W2017241872 countsByYear W20172418722014 @default.
• W2017241872 countsByYear W20172418722015 @default.
• W2017241872 countsByYear W20172418722016 @default.
• W2017241872 countsByYear W20172418722018 @default.
• W2017241872 countsByYear W20172418722019 @default.
• W2017241872 countsByYear W20172418722020 @default.
• W2017241872 countsByYear W20172418722021 @default.
• W2017241872 crossrefType "journal-article" @default.
• W2017241872 hasAuthorship W2017241872A5046578220 @default.
• W2017241872 hasAuthorship W2017241872A5060606567 @default.
• W2017241872 hasAuthorship W2017241872A5069223310 @default.
• W2017241872 hasConcept C104317684 @default.
• W2017241872 hasConcept C12554922 @default.
• W2017241872 hasConcept C144464004 @default.
• W2017241872 hasConcept C185592680 @default.
• W2017241872 hasConcept C2777346074 @default.
• W2017241872 hasConcept C2777637488 @default.
• W2017241872 hasConcept C2778944004 @default.
• W2017241872 hasConcept C39944091 @default.
• W2017241872 hasConcept C41625074 @default.
• W2017241872 hasConcept C523546767 @default.
• W2017241872 hasConcept C54355233 @default.
• W2017241872 hasConcept C55493867 @default.
• W2017241872 hasConcept C58123911 @default.
• W2017241872 hasConcept C86803240 @default.
• W2017241872 hasConcept C89423630 @default.
• W2017241872 hasConceptScore W2017241872C104317684 @default.
• W2017241872 hasConceptScore W2017241872C12554922 @default.
• W2017241872 hasConceptScore W2017241872C144464004 @default.
• W2017241872 hasConceptScore W2017241872C185592680 @default.
• W2017241872 hasConceptScore W2017241872C2777346074 @default.
• W2017241872 hasConceptScore W2017241872C2777637488 @default.
• W2017241872 hasConceptScore W2017241872C2778944004 @default.
• W2017241872 hasConceptScore W2017241872C39944091 @default.
• W2017241872 hasConceptScore W2017241872C41625074 @default.
• W2017241872 hasConceptScore W2017241872C523546767 @default.
• W2017241872 hasConceptScore W2017241872C54355233 @default.
• W2017241872 hasConceptScore W2017241872C55493867 @default.
• W2017241872 hasConceptScore W2017241872C58123911 @default.
• W2017241872 hasConceptScore W2017241872C86803240 @default.
• W2017241872 hasConceptScore W2017241872C89423630 @default.
• W2017241872 hasFunder F4320320691 @default.
• W2017241872 hasFunder F4320320717 @default.
• W2017241872 hasFunder F4320320720 @default.
• W2017241872 hasIssue "6" @default.
• W2017241872 hasLocation W20172418721 @default.
• W2017241872 hasLocation W20172418722 @default.

• next