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- W2017242718 abstract "Abstract: We report an autopsy case of traumatic brain injury (TBI) that presented clinically as frontotemporal dementia (FTD) with Klüver-Bucy syndrome after a one-year latency period. The head injury was relatively slight, and clouding of consciousness was not noted at the time. Repeated CT scans demonstrated no obvious cerebral contusions. The case presented with four of six core symptoms of the Klüver-Bucy syndrome, including hyperorality, changes in emotional behavior (aggression and impulsiveness), hypersexuality, and bulimia. Histopathological examination revealed small cerebral contusions in the bilateral temporal lobe. Loss of myelin and axons was also revealed, especially in the base of the frontotemporal lobe. The laminar structure in the frontotemporal cortex was well preserved. No Pick bodies or Pick's inflated cells were demonstrated by Bodian staining in any region. In the contusions, a small amount of hemosiderin was deposited. In the Lund and Manchester group's research criteria for frontotemporal dementia, head trauma related to the onset of dementia is one of the diagnostic exclusion features. However, 1) assessment of whether a past minor head injury is related to the onset of dementia after a long latency is controversial, and 2) a subset of the TBI cases might be difficult to distinguish from FTD. Further analysis of autopsy cases presenting as FTD following a minor head injury might provide important clues to differentiate clinically FTD from TBI." @default.
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- W2017242718 date "2001-12-01" @default.
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- W2017242718 title "An Autopsy Case of Traumatic Brain Injury (TBI) Presenting as Frontotemporal Dementia with Klüver-Bucy Syndrome" @default.
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- W2017242718 doi "https://doi.org/10.1111/j.1479-8301.2001.tb00023.x" @default.
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