FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017243546> ?p ?o ?g. }

• W2017243546 endingPage "50" @default.
• W2017243546 startingPage "45" @default.
• W2017243546 abstract "Delayed-rectifier Kv2.1 channels are the principal component of voltage-sensitive K+ currents (I(K)) in hippocampal neurons and are critical regulators of somatodendritic excitability. In a recent study, we demonstrated that surface trafficking and phosphorylation of Kv2.1 channels is modulated by NMDA-type glutamate receptors and that astroglial excitatory amino acid transporters 2 (EAAT2) regulate the coupling of NMDA receptors and Kv2.1 channels. Because ethanol is known to acutely inhibit NMDA receptors, we sought to determine if NMDA receptor and astroglial EAAT2 modulation of Kv2.1 channels is impaired by ethanol in the rodent hippocampus. As expected, bath application of NMDA to hippocampal cultures reduced the size of Kv2.1 clusters and produced a hyperpolarizing shift in the voltage-dependent activation of I(K) that was associated with dephosphorylated Kv2.1 channels. Ethanol, applied acutely, prevented the hyperpolarizing shift in activation of I(K) induced by NMDA and restored Kv2.1 clustering and phosphorylation to near control levels. Ethanol also attenuated the dephosphorylation of Kv2.1 channels produced by the EAAT2 selective inhibitor dihydrokainic acid. These data demonstrate that acute ethanol disrupts changes in Kv2.1 channels that follow NMDA receptor activation and impairs astroglial regulation of the functional coupling between NMDA receptors and Kv2.1 channels." @default.
• W2017243546 created "2016-06-24" @default.
• W2017243546 creator A5020003657 @default.
• W2017243546 creator A5051589166 @default.
• W2017243546 creator A5066176863 @default.
• W2017243546 creator A5081525770 @default.
• W2017243546 date "2009-02-01" @default.
• W2017243546 modified "2023-09-26" @default.
• W2017243546 title "Ethanol disrupts NMDA receptor and astroglial EAAT2 modulation of Kv2.1 potassium channels in hippocampus" @default.
• W2017243546 cites W1555529117 @default.
• W2017243546 cites W1571617145 @default.
• W2017243546 cites W1979106875 @default.
• W2017243546 cites W1983807711 @default.
• W2017243546 cites W1994664430 @default.
• W2017243546 cites W1996589818 @default.
• W2017243546 cites W2011135844 @default.
• W2017243546 cites W2034253733 @default.
• W2017243546 cites W2035891650 @default.
• W2017243546 cites W2044081332 @default.
• W2017243546 cites W2073537077 @default.
• W2017243546 cites W2079762354 @default.
• W2017243546 cites W2080633827 @default.
• W2017243546 cites W2086998659 @default.
• W2017243546 cites W2099949778 @default.
• W2017243546 cites W2104417933 @default.
• W2017243546 cites W2109078104 @default.
• W2017243546 cites W2118788831 @default.
• W2017243546 cites W2136920852 @default.
• W2017243546 cites W2138524791 @default.
• W2017243546 cites W2141814544 @default.
• W2017243546 cites W2151942667 @default.
• W2017243546 cites W2152802672 @default.
• W2017243546 cites W2156094132 @default.
• W2017243546 cites W2164938885 @default.
• W2017243546 cites W4210979710 @default.
• W2017243546 cites W4242399160 @default.
• W2017243546 cites W47640489 @default.
• W2017243546 doi "https://doi.org/10.1016/j.alcohol.2008.10.001" @default.
• W2017243546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2674284" @default.
• W2017243546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19185209" @default.
• W2017243546 hasPublicationYear "2009" @default.
• W2017243546 type Work @default.
• W2017243546 sameAs 2017243546 @default.
• W2017243546 citedByCount "24" @default.
• W2017243546 countsByYear W20172435462012 @default.
• W2017243546 countsByYear W20172435462013 @default.
• W2017243546 countsByYear W20172435462014 @default.
• W2017243546 countsByYear W20172435462015 @default.
• W2017243546 countsByYear W20172435462016 @default.
• W2017243546 countsByYear W20172435462017 @default.
• W2017243546 countsByYear W20172435462018 @default.
• W2017243546 countsByYear W20172435462020 @default.
• W2017243546 countsByYear W20172435462021 @default.
• W2017243546 countsByYear W20172435462022 @default.
• W2017243546 countsByYear W20172435462023 @default.
• W2017243546 crossrefType "journal-article" @default.
• W2017243546 hasAuthorship W2017243546A5020003657 @default.
• W2017243546 hasAuthorship W2017243546A5051589166 @default.
• W2017243546 hasAuthorship W2017243546A5066176863 @default.
• W2017243546 hasAuthorship W2017243546A5081525770 @default.
• W2017243546 hasBestOaLocation W20172435462 @default.
• W2017243546 hasConcept C112592302 @default.
• W2017243546 hasConcept C148762608 @default.
• W2017243546 hasConcept C169760540 @default.
• W2017243546 hasConcept C170493617 @default.
• W2017243546 hasConcept C185592680 @default.
• W2017243546 hasConcept C2781161787 @default.
• W2017243546 hasConcept C55493867 @default.
• W2017243546 hasConcept C61174792 @default.
• W2017243546 hasConcept C67018056 @default.
• W2017243546 hasConcept C86803240 @default.
• W2017243546 hasConcept C95444343 @default.
• W2017243546 hasConceptScore W2017243546C112592302 @default.
• W2017243546 hasConceptScore W2017243546C148762608 @default.
• W2017243546 hasConceptScore W2017243546C169760540 @default.
• W2017243546 hasConceptScore W2017243546C170493617 @default.
• W2017243546 hasConceptScore W2017243546C185592680 @default.
• W2017243546 hasConceptScore W2017243546C2781161787 @default.
• W2017243546 hasConceptScore W2017243546C55493867 @default.
• W2017243546 hasConceptScore W2017243546C61174792 @default.
• W2017243546 hasConceptScore W2017243546C67018056 @default.
• W2017243546 hasConceptScore W2017243546C86803240 @default.
• W2017243546 hasConceptScore W2017243546C95444343 @default.
• W2017243546 hasIssue "1" @default.
• W2017243546 hasLocation W20172435461 @default.
• W2017243546 hasLocation W20172435462 @default.
• W2017243546 hasLocation W20172435463 @default.
• W2017243546 hasLocation W20172435464 @default.
• W2017243546 hasOpenAccess W2017243546 @default.
• W2017243546 hasPrimaryLocation W20172435461 @default.
• W2017243546 hasRelatedWork W1501306774 @default.
• W2017243546 hasRelatedWork W1955943544 @default.
• W2017243546 hasRelatedWork W2010108080 @default.
• W2017243546 hasRelatedWork W2018213389 @default.
• W2017243546 hasRelatedWork W2138730144 @default.
• W2017243546 hasRelatedWork W2783633930 @default.
• W2017243546 hasRelatedWork W2980640576 @default.
• W2017243546 hasRelatedWork W3033872672 @default.

• next