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- W2017244785 abstract "We have studied the ability of the Drosophila gap proteins Krüppel and hunchback to function as transcriptional regulators in cultured cells. Both proteins bind to specific sites in a 100-bp DNA fragment located upstream of the segment polarity gene engrailed, which also contains functional binding sites for a number of homeo box proteins. The hunchback protein is a strikingly concentration-dependent activator of transcription, capable of functioning both by itself and also synergistically with the pair-rule proteins fushi tarazu and paired. In contrast, Krüppel is a transcriptional repressor that can block transcription induced either by hunchback or by several different homeo box proteins. While repression of the homeo box protein activators requires a Krüppel-binding site on the DNA, repression of hunchback can occur efficiently in the absence of a Krüppel-binding site. We discuss the possible molecular mechanisms underlying these activities, as well as the potential significance of these results with respect to segmentation in Drosophila." @default.
- W2017244785 created "2016-06-24" @default.
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- W2017244785 date "1991-02-01" @default.
- W2017244785 modified "2023-09-25" @default.
- W2017244785 title "Activation and repression of transcription by the gap proteins hunchback and Krüppel in cultured Drosophila cells." @default.
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- W2017244785 doi "https://doi.org/10.1101/gad.5.2.254" @default.
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