Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017244870> ?p ?o ?g. }
- W2017244870 endingPage "211" @default.
- W2017244870 startingPage "203" @default.
- W2017244870 abstract "Malignant hyperthermia (MH) is caused by increased calcium release from sarcoplasmic reticulum, triggered by volatile anesthetics or depolarizing muscle relaxants. Numerous mutations associated with MH have been detected in the skeletal muscle type ryanodine receptor gene (RyR1), but so far facilitated calcium release has only been demonstrated for a few of them. This is a prerequisite for confirming the causative role of an RyR1 mutation for MH. Calcium release from sarcoplasmic reticulum induced by 4-chloro-m-cresol (4CmC), caffeine, and halothane was determined in human myotubes by calcium imaging. The RyR1 Ile2182Phe mutation and the RyR1 Gly2375Ala mutation have been identified in individuals susceptible to MH. In myotubes of individuals carrying the RyR1 Ile2182Phe or the RyR1 Gly2375Ala mutation, the EC50 for caffeine and halothane was reduced; in the Ile2182Phe myotubes, the EC50 for 4CmC was also reduced, all consistent with facilitated calcium release from the sarcoplasmic reticulum. From these data we conclude that both mutations are pathogenic for MH." @default.
- W2017244870 created "2016-06-24" @default.
- W2017244870 creator A5010119665 @default.
- W2017244870 creator A5014824637 @default.
- W2017244870 creator A5017735010 @default.
- W2017244870 creator A5027098549 @default.
- W2017244870 date "2003-09-01" @default.
- W2017244870 modified "2023-10-14" @default.
- W2017244870 title "Calcium Release from Sarcoplasmic Reticulum Is Facilitated in Human Myotubes Derived from Carriers of the Ryanodine Receptor Type 1 Mutations Ile2182Phe and Gly2375Ala" @default.
- W2017244870 cites W1558371851 @default.
- W2017244870 cites W1969581020 @default.
- W2017244870 cites W1979134839 @default.
- W2017244870 cites W1981753053 @default.
- W2017244870 cites W2015879884 @default.
- W2017244870 cites W2017903490 @default.
- W2017244870 cites W2020232993 @default.
- W2017244870 cites W2029624664 @default.
- W2017244870 cites W2034937610 @default.
- W2017244870 cites W2042794216 @default.
- W2017244870 cites W2047664621 @default.
- W2017244870 cites W2048551240 @default.
- W2017244870 cites W2050199236 @default.
- W2017244870 cites W2050488043 @default.
- W2017244870 cites W2052133214 @default.
- W2017244870 cites W2070530153 @default.
- W2017244870 cites W2085024162 @default.
- W2017244870 cites W2107208446 @default.
- W2017244870 cites W2136779301 @default.
- W2017244870 cites W2141260882 @default.
- W2017244870 cites W2141547153 @default.
- W2017244870 cites W2143130208 @default.
- W2017244870 cites W2146469079 @default.
- W2017244870 cites W2147283436 @default.
- W2017244870 cites W2153379369 @default.
- W2017244870 cites W2160853515 @default.
- W2017244870 cites W2170776735 @default.
- W2017244870 cites W2240467006 @default.
- W2017244870 cites W2411375269 @default.
- W2017244870 cites W4232642333 @default.
- W2017244870 cites W4248197639 @default.
- W2017244870 doi "https://doi.org/10.1089/109065703322537214" @default.
- W2017244870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14641996" @default.
- W2017244870 hasPublicationYear "2003" @default.
- W2017244870 type Work @default.
- W2017244870 sameAs 2017244870 @default.
- W2017244870 citedByCount "14" @default.
- W2017244870 countsByYear W20172448702014 @default.
- W2017244870 countsByYear W20172448702020 @default.
- W2017244870 countsByYear W20172448702021 @default.
- W2017244870 countsByYear W20172448702022 @default.
- W2017244870 countsByYear W20172448702023 @default.
- W2017244870 crossrefType "journal-article" @default.
- W2017244870 hasAuthorship W2017244870A5010119665 @default.
- W2017244870 hasAuthorship W2017244870A5014824637 @default.
- W2017244870 hasAuthorship W2017244870A5017735010 @default.
- W2017244870 hasAuthorship W2017244870A5027098549 @default.
- W2017244870 hasConcept C104317684 @default.
- W2017244870 hasConcept C113217602 @default.
- W2017244870 hasConcept C126322002 @default.
- W2017244870 hasConcept C134018914 @default.
- W2017244870 hasConcept C158617107 @default.
- W2017244870 hasConcept C185592680 @default.
- W2017244870 hasConcept C190712762 @default.
- W2017244870 hasConcept C2776333580 @default.
- W2017244870 hasConcept C2778500429 @default.
- W2017244870 hasConcept C2778575482 @default.
- W2017244870 hasConcept C2779959927 @default.
- W2017244870 hasConcept C3763915 @default.
- W2017244870 hasConcept C42219234 @default.
- W2017244870 hasConcept C501734568 @default.
- W2017244870 hasConcept C519063684 @default.
- W2017244870 hasConcept C55493867 @default.
- W2017244870 hasConcept C71924100 @default.
- W2017244870 hasConcept C86803240 @default.
- W2017244870 hasConceptScore W2017244870C104317684 @default.
- W2017244870 hasConceptScore W2017244870C113217602 @default.
- W2017244870 hasConceptScore W2017244870C126322002 @default.
- W2017244870 hasConceptScore W2017244870C134018914 @default.
- W2017244870 hasConceptScore W2017244870C158617107 @default.
- W2017244870 hasConceptScore W2017244870C185592680 @default.
- W2017244870 hasConceptScore W2017244870C190712762 @default.
- W2017244870 hasConceptScore W2017244870C2776333580 @default.
- W2017244870 hasConceptScore W2017244870C2778500429 @default.
- W2017244870 hasConceptScore W2017244870C2778575482 @default.
- W2017244870 hasConceptScore W2017244870C2779959927 @default.
- W2017244870 hasConceptScore W2017244870C3763915 @default.
- W2017244870 hasConceptScore W2017244870C42219234 @default.
- W2017244870 hasConceptScore W2017244870C501734568 @default.
- W2017244870 hasConceptScore W2017244870C519063684 @default.
- W2017244870 hasConceptScore W2017244870C55493867 @default.
- W2017244870 hasConceptScore W2017244870C71924100 @default.
- W2017244870 hasConceptScore W2017244870C86803240 @default.
- W2017244870 hasIssue "3" @default.
- W2017244870 hasLocation W20172448701 @default.
- W2017244870 hasLocation W20172448702 @default.
- W2017244870 hasOpenAccess W2017244870 @default.
- W2017244870 hasPrimaryLocation W20172448701 @default.
- W2017244870 hasRelatedWork W1505067368 @default.