Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017245609> ?p ?o ?g. }
- W2017245609 endingPage "420" @default.
- W2017245609 startingPage "413" @default.
- W2017245609 abstract "The hypermethylation of estrogen receptor alpha (ERα) promoter is a common molecular alteration in sporadic breast cancer (BC), but its involvement in familial BC remains largely unknown. In the present study, we analyzed the methylation statuses of four regions (ER1, ER3, ER4, and ER5) of the ERα promoter and the ERα expression levels of 113 familial BC patients in a Han Chinese Population from northeastern China and evaluated the association between major clinicopathological features and the hypermethylation statuses of the ERα gene. Tumor samples were analyzed for ERα methylation status by the methylation-specific polymerase chain reaction for ERα, PR, p53, BRCA-1, and BRCA-2 by immunohistochemical (IHC) staining and for Her-2 status by IHC and fluorescence in situ hybridization (FISH). ERα methylation was observed in tumor tissues in 47/113 (41.6%) familial BC patients. There were no significant differences in the methylation statuses among ER1 (20.4%), ER3 (18.6%), ER4 (17.7%), and ER5 (19.5%; χ 2 = 3.89, p > 0.05). An association between ERα expression level and its promoter methylation level was found. In addition, ERα methylation was significantly correlated with tumor size, PR expression, p53 nuclear accumulation, and BRCA-1 and BRCA-2 statuses. In conclusion, in familial BC patients, the level of ERα gene promoter methylation correlates with ERα expression, PR, p53 nuclear accumulation, and BRCA-1 and BRCA-2 statuses. Epigenetic alteration of ERα gene may play an important role in the pathogenesis of familial BC." @default.
- W2017245609 created "2016-06-24" @default.
- W2017245609 creator A5010742292 @default.
- W2017245609 creator A5015598217 @default.
- W2017245609 creator A5018000360 @default.
- W2017245609 creator A5031666815 @default.
- W2017245609 creator A5084063375 @default.
- W2017245609 creator A5091275779 @default.
- W2017245609 date "2011-09-16" @default.
- W2017245609 modified "2023-09-27" @default.
- W2017245609 title "Promoter methylation status and expression of estrogen receptor alpha in familial breast cancer patients" @default.
- W2017245609 cites W1881540319 @default.
- W2017245609 cites W1974864037 @default.
- W2017245609 cites W1978553767 @default.
- W2017245609 cites W1983626331 @default.
- W2017245609 cites W1984566339 @default.
- W2017245609 cites W1988431978 @default.
- W2017245609 cites W1994465394 @default.
- W2017245609 cites W1997038527 @default.
- W2017245609 cites W2007470097 @default.
- W2017245609 cites W2020007184 @default.
- W2017245609 cites W2022849751 @default.
- W2017245609 cites W2024848743 @default.
- W2017245609 cites W2036649240 @default.
- W2017245609 cites W2043053726 @default.
- W2017245609 cites W2043925970 @default.
- W2017245609 cites W2046243732 @default.
- W2017245609 cites W2046941700 @default.
- W2017245609 cites W2047622651 @default.
- W2017245609 cites W2052013412 @default.
- W2017245609 cites W2085129453 @default.
- W2017245609 cites W2089478002 @default.
- W2017245609 cites W2095975057 @default.
- W2017245609 cites W2096444893 @default.
- W2017245609 cites W2099312447 @default.
- W2017245609 cites W2101193350 @default.
- W2017245609 cites W2101615377 @default.
- W2017245609 cites W2106061838 @default.
- W2017245609 cites W2113778933 @default.
- W2017245609 cites W2137518082 @default.
- W2017245609 cites W2143474295 @default.
- W2017245609 cites W2148876744 @default.
- W2017245609 cites W2158324531 @default.
- W2017245609 cites W2166082627 @default.
- W2017245609 cites W2166869851 @default.
- W2017245609 doi "https://doi.org/10.1007/s13277-011-0234-x" @default.
- W2017245609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21922275" @default.
- W2017245609 hasPublicationYear "2011" @default.
- W2017245609 type Work @default.
- W2017245609 sameAs 2017245609 @default.
- W2017245609 citedByCount "23" @default.
- W2017245609 countsByYear W20172456092012 @default.
- W2017245609 countsByYear W20172456092013 @default.
- W2017245609 countsByYear W20172456092014 @default.
- W2017245609 countsByYear W20172456092015 @default.
- W2017245609 countsByYear W20172456092016 @default.
- W2017245609 countsByYear W20172456092017 @default.
- W2017245609 countsByYear W20172456092019 @default.
- W2017245609 countsByYear W20172456092020 @default.
- W2017245609 countsByYear W20172456092021 @default.
- W2017245609 countsByYear W20172456092022 @default.
- W2017245609 countsByYear W20172456092023 @default.
- W2017245609 crossrefType "journal-article" @default.
- W2017245609 hasAuthorship W2017245609A5010742292 @default.
- W2017245609 hasAuthorship W2017245609A5015598217 @default.
- W2017245609 hasAuthorship W2017245609A5018000360 @default.
- W2017245609 hasAuthorship W2017245609A5031666815 @default.
- W2017245609 hasAuthorship W2017245609A5084063375 @default.
- W2017245609 hasAuthorship W2017245609A5091275779 @default.
- W2017245609 hasConcept C101762097 @default.
- W2017245609 hasConcept C104317684 @default.
- W2017245609 hasConcept C121608353 @default.
- W2017245609 hasConcept C150194340 @default.
- W2017245609 hasConcept C153911025 @default.
- W2017245609 hasConcept C172313692 @default.
- W2017245609 hasConcept C190727270 @default.
- W2017245609 hasConcept C203014093 @default.
- W2017245609 hasConcept C204232928 @default.
- W2017245609 hasConcept C2777542201 @default.
- W2017245609 hasConcept C30481170 @default.
- W2017245609 hasConcept C33288867 @default.
- W2017245609 hasConcept C41091548 @default.
- W2017245609 hasConcept C502942594 @default.
- W2017245609 hasConcept C530470458 @default.
- W2017245609 hasConcept C54355233 @default.
- W2017245609 hasConcept C84606932 @default.
- W2017245609 hasConcept C86803240 @default.
- W2017245609 hasConcept C96307122 @default.
- W2017245609 hasConceptScore W2017245609C101762097 @default.
- W2017245609 hasConceptScore W2017245609C104317684 @default.
- W2017245609 hasConceptScore W2017245609C121608353 @default.
- W2017245609 hasConceptScore W2017245609C150194340 @default.
- W2017245609 hasConceptScore W2017245609C153911025 @default.
- W2017245609 hasConceptScore W2017245609C172313692 @default.
- W2017245609 hasConceptScore W2017245609C190727270 @default.
- W2017245609 hasConceptScore W2017245609C203014093 @default.
- W2017245609 hasConceptScore W2017245609C204232928 @default.
- W2017245609 hasConceptScore W2017245609C2777542201 @default.