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• W2017246888 abstract "Abstract The hypothalamic–pituitary–adrenal (HPA) axis functions to coordinate behavioural and physiological responses to stress in a manner that depends on the behavioural state of the organism. However, the mechanisms through which arousal and metabolic states influence the HPA axis are poorly understood. Here using optogenetic approaches in mice, we show that neurons that produce hypocretin (Hcrt)/orexin in the lateral hypothalamic area (LHA) regulate corticosterone release and a variety of behaviours and physiological hallmarks of the stress response. Interestingly, we found that Hcrt neuronal activity and Hcrt-mediated stress responses were inhibited by the satiety hormone leptin, which acts, in part, through a network of leptin-sensitive neurons in the LHA. These data demonstrate how peripheral metabolic signals interact with hypothalamic neurons to coordinate stress and arousal and suggest one mechanism through which hyperarousal or altered metabolic states may be linked with abnormal stress responses." @default.
• W2017246888 created "2016-06-24" @default.
• W2017246888 creator A5005132242 @default.
• W2017246888 creator A5022455904 @default.
• W2017246888 creator A5055709520 @default.
• W2017246888 creator A5071317547 @default.
• W2017246888 date "2015-02-19" @default.
• W2017246888 modified "2023-10-01" @default.
• W2017246888 title "Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses" @default.
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• W2017246888 doi "https://doi.org/10.1038/ncomms7266" @default.
• W2017246888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4335349" @default.
• W2017246888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25695914" @default.
• W2017246888 hasPublicationYear "2015" @default.
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