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• W2017247601 abstract "This prospective study demonstrates early encouraging clinical and radiological outcomes in patients treated with arthroscopically performed matrix-induced autologous chondrocyte implantation (MACI), combined with an ‘accelerated’ return to full weight bearing (WB). This prospective study demonstrates early encouraging clinical and radiological outcomes in patients treated with arthroscopically performed matrix-induced autologous chondrocyte implantation (MACI), combined with an ‘accelerated’ return to full weight bearing (WB). Twenty patients with full-thickness defects to the femoral or tibial condyles were treated with MACI performed arthroscopically. Following preparation of the graft site, fibrin glue was introduced, and the membrane was held in place with an even pressure applied by inflating the balloon end of a silastic urinary catheter. Following surgery, patients underwent a graduated rehabilitation program that aimed to protect the implant initially, then incrementally increase the load until full WB was attained at 8-weeks post-surgery. Clinical outcomes were measured pre-surgery and at 3, 6 and 12 months post-surgery using the Knee Injury and Osteoarthritis Outcome Score (KOOS), the visual analogue pain scale (VAS), the six-minute walk test and knee range of motion. Clinical outcomes were compared with previously established clinical scores from patients who had undergone MACI performed through open arthrotomy, in combination with an identical, accelerated rehabilitation protocol. High resolution magnetic resonance imaging (MRI) was undertaken at 3 and 12 months post-surgery to describe the quality and quantity of repair tissue. From pre-surgery to 12 months post-surgery, KOOS and VAS scores demonstrated significant improvement (p<0.05), though there was no difference (p>0.05) to patients who underwent open arthrotomic MACI in combination with accelerated rehabilitation. There was no difference (p>0.05) in six-minute walk distance, though significantly better (p<0.05) active knee flexion was observed at 3 and 6 months in the arthroscopic MACI group. Patients demonstrated an increased MRI composite score over time that improved significantly (p<0.05) from three to 12 months post-surgery, but did not differ (p>0.05) from patients following MACI performed through open arthrotomy. Arthroscopic MACI in combination with ‘accelerated’ rehabilitation has shown encouraging early results, with good early graft infill and no graft complications. Arthroscopically performed MACI may reduce the co-morbidity associated with open arthrotomy, such as adhesions, decreased range of motion, pain and impressive scars, whilst providing faster post-operative rehabilitation due to reduced pain and muscular deficits. A larger patient cohort and follow-up is required to observe long-term graft outcomes." @default.
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• W2017247601 date "2011-10-01" @default.
• W2017247601 modified "2023-09-23" @default.
• W2017247601 title "Paper # 183: Arthroscopic Matrix-Induced Autologous Chondrocyte Implantation (MACI)" @default.
• W2017247601 doi "https://doi.org/10.1016/j.arthro.2011.08.183" @default.
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