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• W2017247807 endingPage "445" @default.
• W2017247807 startingPage "429" @default.
• W2017247807 abstract "The majority of studies of fetal hepatic elimination have concentrated on the expression and activity of the metabolizing enzymes, but the unique physiologic milieu of the fetal liver should also be considered. The basic structure of the liver is formed by the end of the first trimester. The fetal hepatic circulation differs substantially from that of the adult in that there is an extra input vessel, the umbilical vein, and there is shunting of 30-70% of hepatic blood flow via the ductus venosus. The left and right lobes of the fetal liver seem to function independently with respect to a variety of biochemical parameters, due at least in part to the lower oxygen supply to the right lobe. The zonation of drug-metabolizing enzymes along the hepatic acinus, which is prominent in the adult liver, is absent in the fetal liver. Unlike rodent species, the human fetal liver has a significant capacity for drug metabolism. Of the oxidative enzymes, CYP3A7 accounts for up to 50% of total fetal hepatic cytochrome P450 content. Expression of this enzyme decreases dramatically after birth. CYP1A1 and CYP2D6 have also been detected in human fetal liver, but whether CYP2E1 is expressed remains controversial. Several other cytochrome P450s have been identified and await characterization. Fetal hepatic drug conjugation may prolong fetal exposure to the metabolites produced, which, being more water soluble, do not readily cross the placenta back to the mother and, if excreted in fetal urine, can be recycled in the fetus via amniotic fluid and fetal swallowing. Limited activity of glucuronidation enzymes has been demonstrated in human fetal liver in contrast to the activity of sulfation enzymes, which is significant. Limited in vivo studies in fetal sheep have demonstrated significant fetal hepatic drug elimination, and this has been confirmed in studies of the isolated perfused fetal sheep liver. Our understanding of fetal hepatic elimination processes has advanced steadily over the years. Future developments, however, should consider more fully the influence of the unique physiological milieu of the fetal liver, in addition to the expression and activity of drug metabolizing enzymes." @default.
• W2017247807 created "2016-06-24" @default.
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• W2017247807 date "1999-12-01" @default.
• W2017247807 modified "2023-10-14" @default.
• W2017247807 title "Fetal hepatic drug elimination" @default.
• W2017247807 cites W1004452157 @default.
• W2017247807 cites W107868517 @default.
• W2017247807 cites W1491051927 @default.
• W2017247807 cites W1492188531 @default.
• W2017247807 cites W1492349568 @default.
• W2017247807 cites W1523711413 @default.
• W2017247807 cites W1527926648 @default.
• W2017247807 cites W1528997672 @default.
• W2017247807 cites W1558694706 @default.
• W2017247807 cites W1565212514 @default.
• W2017247807 cites W1565963242 @default.
• W2017247807 cites W1581885355 @default.
• W2017247807 cites W1859354720 @default.
• W2017247807 cites W1878615384 @default.
• W2017247807 cites W1903394488 @default.
• W2017247807 cites W1920965755 @default.
• W2017247807 cites W1954463628 @default.
• W2017247807 cites W1970068093 @default.
• W2017247807 cites W1972683398 @default.
• W2017247807 cites W1975024270 @default.
• W2017247807 cites W1981435376 @default.
• W2017247807 cites W1985757623 @default.
• W2017247807 cites W1989620197 @default.
• W2017247807 cites W1991292721 @default.
• W2017247807 cites W1992693612 @default.
• W2017247807 cites W1994029494 @default.
• W2017247807 cites W1995993782 @default.
• W2017247807 cites W2000742403 @default.
• W2017247807 cites W2001218108 @default.
• W2017247807 cites W2001733705 @default.
• W2017247807 cites W2007683049 @default.
• W2017247807 cites W2008931994 @default.
• W2017247807 cites W2010979947 @default.
• W2017247807 cites W2011317980 @default.
• W2017247807 cites W2013170487 @default.
• W2017247807 cites W2016335393 @default.
• W2017247807 cites W2018768627 @default.
• W2017247807 cites W2019680914 @default.
• W2017247807 cites W2021789550 @default.
• W2017247807 cites W2021878044 @default.
• W2017247807 cites W2022221107 @default.
• W2017247807 cites W2022390689 @default.
• W2017247807 cites W2022918187 @default.
• W2017247807 cites W2023769846 @default.
• W2017247807 cites W2024070809 @default.
• W2017247807 cites W2025420669 @default.
• W2017247807 cites W2025739619 @default.
• W2017247807 cites W2025853015 @default.
• W2017247807 cites W2026548621 @default.
• W2017247807 cites W2027414922 @default.
• W2017247807 cites W2028890133 @default.
• W2017247807 cites W2029969254 @default.
• W2017247807 cites W2030924706 @default.
• W2017247807 cites W2032186493 @default.
• W2017247807 cites W2034823318 @default.
• W2017247807 cites W2035887467 @default.
• W2017247807 cites W2037422091 @default.
• W2017247807 cites W203956216 @default.
• W2017247807 cites W2040481349 @default.
• W2017247807 cites W2041718860 @default.
• W2017247807 cites W2044681712 @default.
• W2017247807 cites W2045074190 @default.
• W2017247807 cites W2046768871 @default.
• W2017247807 cites W2047112694 @default.
• W2017247807 cites W2047804798 @default.
• W2017247807 cites W2049017286 @default.
• W2017247807 cites W2049464424 @default.
• W2017247807 cites W2051755502 @default.
• W2017247807 cites W2055566818 @default.
• W2017247807 cites W2056096245 @default.
• W2017247807 cites W2058811406 @default.
• W2017247807 cites W2059293500 @default.
• W2017247807 cites W2061717797 @default.
• W2017247807 cites W2062510283 @default.
• W2017247807 cites W2063170491 @default.
• W2017247807 cites W2063792000 @default.
• W2017247807 cites W2063986174 @default.
• W2017247807 cites W2065572118 @default.
• W2017247807 cites W2067162304 @default.
• W2017247807 cites W2067488135 @default.
• W2017247807 cites W2069734079 @default.
• W2017247807 cites W2071508563 @default.
• W2017247807 cites W2073910977 @default.
• W2017247807 cites W2074361153 @default.
• W2017247807 cites W2074667461 @default.
• W2017247807 cites W2074809625 @default.
• W2017247807 cites W2074952015 @default.
• W2017247807 cites W2076617730 @default.

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