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- W2017248048 abstract "The important role of platelets in the development of arterial thrombosis and cardiovascular disease is well established. Current treatments for arterial thrombosis include anti-platelet agents such as aspirin, thienopyridines and glycoprotein IIb–IIIa inhibitors. Despite these drugs being effective there remains a substantial unmet clinical demand for more effective therapeutic approaches, which may reflect the existence of alternative underlying regulatory mechanisms to those already targeted. Recent publications have demonstrated a key role for tachykinins in the positive feedback regulation of platelet aggregation and thrombus formation. The pro-thrombotic effects of tachykinins on platelets are mediated through the neurokinin 1 receptor, which may therefore offer a novel therapeutic drug target in the prevention and the treatment of arterial thrombosis." @default.
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- W2017248048 date "2008-04-01" @default.
- W2017248048 modified "2023-10-03" @default.
- W2017248048 title "The neurokinin 1 receptor: a potential new target for anti-platelet therapy?" @default.
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- W2017248048 doi "https://doi.org/10.1016/j.coph.2008.01.004" @default.
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