FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017248972> ?p ?o ?g. }

• W2017248972 endingPage "1" @default.
• W2017248972 startingPage "1" @default.
• W2017248972 abstract "In 2011, a new set of new guidelines for the research diagnosis of three stages of Alzheimer disease was promulgated by the US National Institute of Aging and the Alzheimer Association. For the first time, they include the diagnosis of presymptomatic Alzheimer disease, recognizing that the disease process begins years before cognitive impairment develops. Awareness of this fact has largely been driven by neuroimaging, and particularly by imaging amyloid β (abeta) deposition in the brain, a procedure approved by the US Food and Drug Administration for clinical use in April 2012.In Alzheimer disease, abeta deposition antecedes, probably by decades, the onset of cognitive impairment. In brain regions with greatest abeta deposition, synaptic dysfunction can be imaged beginning at preclinical stages. In regions that are not identical with the ones with greatest abeta deposition but heavily connected with them, regional atrophy and loss of white-matter anisotropy can be detected later in the course of the disease, near the time when mild cognitive impairment supervenes. Together with neuropsychological testing, imaging can improve the prediction of worsening to Alzheimer disease among patients with mild cognitive impairment.These findings have huge implications for research on therapeutic approaches to Alzheimer disease. For instance, while so far only patients with the clinical diagnosis have been treated with immunotherapy targeting abeta removal, a consensus is building that to be effective, this therapy should be given in the preclinical stages of the disease, which are assessed most advantageously by means of neuroimaging." @default.
• W2017248972 created "2016-06-24" @default.
• W2017248972 creator A5028700638 @default.
• W2017248972 creator A5030704950 @default.
• W2017248972 creator A5079197844 @default.
• W2017248972 date "2012-07-01" @default.
• W2017248972 modified "2023-09-29" @default.
• W2017248972 title "The neurobiology of Alzheimer disease defined by neuroimaging" @default.
• W2017248972 cites W1528261366 @default.
• W2017248972 cites W1584481215 @default.
• W2017248972 cites W1916193671 @default.
• W2017248972 cites W1964609915 @default.
• W2017248972 cites W1964965688 @default.
• W2017248972 cites W1965842072 @default.
• W2017248972 cites W1966318978 @default.
• W2017248972 cites W1967320933 @default.
• W2017248972 cites W1968126294 @default.
• W2017248972 cites W1973637437 @default.
• W2017248972 cites W1974594322 @default.
• W2017248972 cites W1979415323 @default.
• W2017248972 cites W1980111435 @default.
• W2017248972 cites W1984748043 @default.
• W2017248972 cites W1986144956 @default.
• W2017248972 cites W1988693860 @default.
• W2017248972 cites W1990134753 @default.
• W2017248972 cites W1990181857 @default.
• W2017248972 cites W1990502495 @default.
• W2017248972 cites W1993303421 @default.
• W2017248972 cites W1994206031 @default.
• W2017248972 cites W1995719450 @default.
• W2017248972 cites W1998633319 @default.
• W2017248972 cites W2001618696 @default.
• W2017248972 cites W2001648635 @default.
• W2017248972 cites W2003428745 @default.
• W2017248972 cites W2009576287 @default.
• W2017248972 cites W2011286803 @default.
• W2017248972 cites W2012191973 @default.
• W2017248972 cites W2014888437 @default.
• W2017248972 cites W2022040401 @default.
• W2017248972 cites W2023121717 @default.
• W2017248972 cites W2025609805 @default.
• W2017248972 cites W2027094862 @default.
• W2017248972 cites W2027110663 @default.
• W2017248972 cites W2027628093 @default.
• W2017248972 cites W2031233001 @default.
• W2017248972 cites W2032977736 @default.
• W2017248972 cites W2040412343 @default.
• W2017248972 cites W2041668529 @default.
• W2017248972 cites W2041792754 @default.
• W2017248972 cites W2042956691 @default.
• W2017248972 cites W2044488773 @default.
• W2017248972 cites W2051489981 @default.
• W2017248972 cites W2053836765 @default.
• W2017248972 cites W2054534656 @default.
• W2017248972 cites W2055635555 @default.
• W2017248972 cites W2056045580 @default.
• W2017248972 cites W2056634527 @default.
• W2017248972 cites W2060295418 @default.
• W2017248972 cites W2060629467 @default.
• W2017248972 cites W2062210296 @default.
• W2017248972 cites W2063151296 @default.
• W2017248972 cites W2068338689 @default.
• W2017248972 cites W2070267512 @default.
• W2017248972 cites W2072361983 @default.
• W2017248972 cites W2072522618 @default.
• W2017248972 cites W2074829442 @default.
• W2017248972 cites W2076960269 @default.
• W2017248972 cites W2084166648 @default.
• W2017248972 cites W2084331437 @default.
• W2017248972 cites W2087924155 @default.
• W2017248972 cites W2088155460 @default.
• W2017248972 cites W2090468420 @default.
• W2017248972 cites W2096570098 @default.
• W2017248972 cites W2098580427 @default.
• W2017248972 cites W2099480013 @default.
• W2017248972 cites W2102263312 @default.
• W2017248972 cites W2105037799 @default.
• W2017248972 cites W2105474070 @default.
• W2017248972 cites W2108216694 @default.
• W2017248972 cites W2109874185 @default.
• W2017248972 cites W2110291356 @default.
• W2017248972 cites W2111425471 @default.
• W2017248972 cites W2112499304 @default.
• W2017248972 cites W2113226008 @default.
• W2017248972 cites W2114555409 @default.
• W2017248972 cites W2115017507 @default.
• W2017248972 cites W2115237892 @default.
• W2017248972 cites W2118753807 @default.
• W2017248972 cites W2121673076 @default.
• W2017248972 cites W2122826986 @default.
• W2017248972 cites W2122843800 @default.
• W2017248972 cites W2126927216 @default.
• W2017248972 cites W2129497119 @default.
• W2017248972 cites W2130126582 @default.
• W2017248972 cites W2130484652 @default.
• W2017248972 cites W2132091452 @default.
• W2017248972 cites W2133280495 @default.
• W2017248972 cites W2133813579 @default.

• next