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- W2017249997 abstract "Melatonin is shown to accumulate within the foetal sheep pineal gland in the last few days of gestation. The mean ± S.E.M. foetal content was 79 ± 25 pg per gland for 30 foetuses obtained from day 124–145 gestation and 836 ± 286 pg per gland for 21 foetuses judged to be within 5 days of birth. In 5 neonates, the mean pineal content on day 1 was 899 ± 280 pg per gland. This accumulation correlates to a rise in tissue hydroxyindole-O-methyltransferase activity and foetal plasma melatonin. The possible relationship between these parameters and the endocrine changes preceding parturition is discussed. Significant levels of monoamine oxidase activity were found in foetal sheep pineal and the possibility is raised of other indoles (e.g. 5-methoxy tryptophol) being of importance in foetal pineal function." @default.
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- W2017249997 date "1977-05-01" @default.
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- W2017249997 title "On the presence of melatonin in pineal glands and plasma of foetal sheep" @default.
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- W2017249997 doi "https://doi.org/10.1016/0022-4731(77)90262-x" @default.
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