Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017251246> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2017251246 endingPage "4063" @default.
- W2017251246 startingPage "4059" @default.
- W2017251246 abstract "N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide isomers (DMNA-NH-CPA, 4) were synthesized stereospecifically from Boc-L-Hse(OBn)-OH and the degradation of the corresponding reduced amine 5a was investigated by UV/vis spectroscopy and LC/MS. The rate of cyclization of 5a was found to increase with decreasing pH, with half-lives ranging from 3.2 to 54 min at pH 4-7.4, suggesting that the cyclization is catalyzed by the hydronium ions. LC/MS analysis of the degradation products of 5a indicates that 4-aminocyclophosphamide is rapidly released from 4 upon reductive activation under acidic conditions and further decomposes into the cytotoxic phosphoramide mustard. These results validated 4-aminocyclophosphamide as a prodrug form of phosphoramide mustard and suggest that compound 4 can potentially be used as a prodrug of phosphoramide mustard for bioreductive activation." @default.
- W2017251246 created "2016-06-24" @default.
- W2017251246 creator A5023312825 @default.
- W2017251246 creator A5024062259 @default.
- W2017251246 date "2008-07-01" @default.
- W2017251246 modified "2023-10-12" @default.
- W2017251246 title "N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide as a potential bioreductively activated prodrug of phosphoramide mustard" @default.
- W2017251246 cites W1975339211 @default.
- W2017251246 cites W1980720739 @default.
- W2017251246 cites W1992598425 @default.
- W2017251246 cites W1995778273 @default.
- W2017251246 cites W1999028855 @default.
- W2017251246 cites W2038966291 @default.
- W2017251246 cites W2041365708 @default.
- W2017251246 cites W2054131903 @default.
- W2017251246 cites W2069579949 @default.
- W2017251246 cites W2088713878 @default.
- W2017251246 cites W2092679838 @default.
- W2017251246 cites W2099372454 @default.
- W2017251246 cites W2111521591 @default.
- W2017251246 cites W2121849454 @default.
- W2017251246 cites W2145829768 @default.
- W2017251246 cites W2342523120 @default.
- W2017251246 cites W4238860218 @default.
- W2017251246 cites W4256300105 @default.
- W2017251246 cites W4316093125 @default.
- W2017251246 doi "https://doi.org/10.1016/j.bmcl.2008.05.099" @default.
- W2017251246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18556201" @default.
- W2017251246 hasPublicationYear "2008" @default.
- W2017251246 type Work @default.
- W2017251246 sameAs 2017251246 @default.
- W2017251246 citedByCount "12" @default.
- W2017251246 countsByYear W20172512462012 @default.
- W2017251246 countsByYear W20172512462013 @default.
- W2017251246 countsByYear W20172512462016 @default.
- W2017251246 countsByYear W20172512462019 @default.
- W2017251246 crossrefType "journal-article" @default.
- W2017251246 hasAuthorship W2017251246A5023312825 @default.
- W2017251246 hasAuthorship W2017251246A5024062259 @default.
- W2017251246 hasConcept C108215921 @default.
- W2017251246 hasConcept C131779359 @default.
- W2017251246 hasConcept C155647269 @default.
- W2017251246 hasConcept C178790620 @default.
- W2017251246 hasConcept C185592680 @default.
- W2017251246 hasConcept C55493867 @default.
- W2017251246 hasConcept C71240020 @default.
- W2017251246 hasConceptScore W2017251246C108215921 @default.
- W2017251246 hasConceptScore W2017251246C131779359 @default.
- W2017251246 hasConceptScore W2017251246C155647269 @default.
- W2017251246 hasConceptScore W2017251246C178790620 @default.
- W2017251246 hasConceptScore W2017251246C185592680 @default.
- W2017251246 hasConceptScore W2017251246C55493867 @default.
- W2017251246 hasConceptScore W2017251246C71240020 @default.
- W2017251246 hasIssue "14" @default.
- W2017251246 hasLocation W20172512461 @default.
- W2017251246 hasLocation W20172512462 @default.
- W2017251246 hasOpenAccess W2017251246 @default.
- W2017251246 hasPrimaryLocation W20172512461 @default.
- W2017251246 hasRelatedWork W1845624145 @default.
- W2017251246 hasRelatedWork W1987755785 @default.
- W2017251246 hasRelatedWork W1994651367 @default.
- W2017251246 hasRelatedWork W2075761790 @default.
- W2017251246 hasRelatedWork W2131216566 @default.
- W2017251246 hasRelatedWork W2403608485 @default.
- W2017251246 hasRelatedWork W2606340465 @default.
- W2017251246 hasRelatedWork W2748537536 @default.
- W2017251246 hasRelatedWork W2951150910 @default.
- W2017251246 hasRelatedWork W2952658421 @default.
- W2017251246 hasVolume "18" @default.
- W2017251246 isParatext "false" @default.
- W2017251246 isRetracted "false" @default.
- W2017251246 magId "2017251246" @default.
- W2017251246 workType "article" @default.