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- W2017252209 abstract "The opioid receptor mechanism involved in the morphine induced straub tail response was investigated in mice. Morphine (2.5, 5, 10 and 20 mg/kg s.c.) produced a dose dependent straub tail response and analgesia (hot plate test). Naloxone (5 mg/kg s.c.) and the μ-opioid receptor antagonist β-funaltrexamine (10 μg i.c.v.) blocked both the straub tail response and analgesia while the μ1-opioid receptor selective antagonist naloxonazine (35 mg/kg s.c.) blocked only analgesia and did not affect the straub tail response. Morphine (20 μg) administered by the i.c.v. route also produced the straub tail response as well as analgesia. Pretreatment with naloxonazine (35 mg/kg s.c.) antagonised i.c.v. administered morphine induced analgesia while the straub tail response was not affected. The results indicate that the morphine induced straub tail response is mediated by central μ2-opioid receptors." @default.
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- W2017252209 date "1994-09-01" @default.
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- W2017252209 title "Morphine-induced straub tail response: Mediated by central μ2-opioid receptor" @default.
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