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• W2017253732 abstract "Objective To determine the relative abilities of somatostatin receptor scintigraphy (SRS) and conventional imaging studies (computed tomography, magnetic resonance imaging, ultrasound, angiography) to localize gastrinomas before surgery in patients with Zollinger-Ellison syndrome (ZES) subsequently found at surgery, and to determine the effect of SRS on the disease-free rate. Summary Background Data Recent studies demonstrate that SRS is the most sensitive imaging modality for localizing neuroendocrine tumors such as gastrinomas. Because of conflicting results in small series, it is unclear in ZES whether SRS will alter the disease-free rate, which gastrinomas are not detected, what factors contribute to failure to detect a gastrinoma, or whether the SRS result should be used to determine operability in patients without hepatic metastases, as recently recommended by some investigators. Methods Thirty-five consecutive patients with ZES undergoing 37 exploratory laparotomies for possible cure were prospectively studied. All had SRS and conventional imaging studies before surgery. Imaging results were determined by an independent investigator depending on surgical findings. All patients underwent an identical surgical protocol (palpation after an extensive Kocher maneuver, ultrasound during surgery, duodenal transillumination, and 3 cm duodenotomy) and postoperative assessment of disease status (fasting gastrin, secretin test imaging within 2 weeks, at 3 to 6 months, and yearly), as used in pre-SRS studies previously. Results Gastrinomas were detected in all patients at each surgery. Seventy-four gastrinomas were found: 22 duodenal, 8 pancreatic, 3 primaries in other sites, and 41 lymph node metastases. The relative detection order on a per-patient or per-lesion basis was SRS > angiography, magnetic resonance imaging, computed tomography > ultrasound. On a per-lesion basis, SRS had greater sensitivity than all conventional studies combined. SRS missed one third of all lesions found at surgery. SRS detected 30% of gastrinomas ≤1.1 cm, 64% of those 1.1 to 2 cm, and 96% of those >2 cm and missed primarily small duodenal tumors. Tumor size correlated closely with SRS rate of detection. SRS did not increase the disease-free rate immediately after surgery or at 2 years mean follow-up. Conclusions SRS is the most sensitive preoperative imaging study for extrahepatic gastrinomas in patients with ZES and should replace conventional imaging studies as the preoperative study of choice. Negative results of SRS for localizing extrahepatic gastrinomas should not be used to decide operability, because a surgical procedure will detect 33% more gastrinomas than SRS. SRS does not increase the disease-free rate. In the future, more sensitive methods to detect small gastrinomas, especially in the duodenum and in periduodenal lymph nodes, or more extensive surgery will be needed to improve the postoperative disease-free rate in ZES." @default.
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• W2017253732 date "1998-08-01" @default.
• W2017253732 modified "2023-10-14" @default.
• W2017253732 title "Prospective Study of Somatostatin Receptor Scintigraphy and its Effect on Operative Outcome in Patients With Zollinger-Ellison Syndrome" @default.
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• W2017253732 cites W1810626043 @default.
• W2017253732 cites W1874691199 @default.
• W2017253732 cites W1964274197 @default.
• W2017253732 cites W1964731243 @default.
• W2017253732 cites W1969184550 @default.
• W2017253732 cites W1973099367 @default.
• W2017253732 cites W1980010816 @default.
• W2017253732 cites W1989753979 @default.
• W2017253732 cites W1990028760 @default.
• W2017253732 cites W2000539223 @default.
• W2017253732 cites W2003157753 @default.
• W2017253732 cites W2005078043 @default.
• W2017253732 cites W2011187030 @default.
• W2017253732 cites W2012753113 @default.
• W2017253732 cites W2013280746 @default.
• W2017253732 cites W2015654204 @default.
• W2017253732 cites W2017835214 @default.
• W2017253732 cites W2026613205 @default.
• W2017253732 cites W2032893342 @default.
• W2017253732 cites W2036017309 @default.
• W2017253732 cites W2036212440 @default.
• W2017253732 cites W2039842131 @default.
• W2017253732 cites W2044577321 @default.
• W2017253732 cites W2045771679 @default.
• W2017253732 cites W2049215320 @default.
• W2017253732 cites W2049666190 @default.
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• W2017253732 cites W2059334599 @default.
• W2017253732 cites W2062288072 @default.
• W2017253732 cites W2065361341 @default.
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• W2017253732 cites W2076825218 @default.
• W2017253732 cites W2079799401 @default.
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• W2017253732 cites W2087503539 @default.
• W2017253732 cites W2092253945 @default.
• W2017253732 cites W2142938452 @default.
• W2017253732 cites W2147989740 @default.
• W2017253732 cites W2337046339 @default.
• W2017253732 cites W2395019708 @default.
• W2017253732 cites W2409310716 @default.
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• W2017253732 doi "https://doi.org/10.1097/00000658-199808000-00013" @default.
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