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- W2017257445 abstract "Cell death through apoptosis plays a critical role in regulating cellular homeostasis. Whether the disposal of apoptotic cells through phagocytosis can actively induce immune tolerance in vivo, however, remains controversial. Here, we report in a rat model that without using immunosuppressants, transfusion of apoptotic splenocytes from the donor strain prior to transplant dramatically prolonged survival of heart allografts. Histological analysis verified that rejection signs were significantly ameliorated. Splenocytes from rats transfused with donor apoptotic cells showed a dramatically decreased response to donor lymphocyte stimulation. Most importantly, blockade of phagocytosis in vivo, either with gadolinium chloride to disrupt phagocyte function or with annexin V to block binding of exposed phosphotidylserine to its receptor on phagocytes, abolished the beneficial effect of transfused apoptotic cells on heart allograft survival. Our results demonstrate that donor apoptotic cells promote specific allograft acceptance and that phagocytosis of apoptotic cells in vivo plays a crucial role in maintaining immune tolerance." @default.
- W2017257445 created "2016-06-24" @default.
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- W2017257445 date "2004-09-17" @default.
- W2017257445 modified "2023-10-12" @default.
- W2017257445 title "Allograft tolerance induced by donor apoptotic lymphocytes requires phagocytosis in the recipient" @default.
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- W2017257445 doi "https://doi.org/10.1038/sj.cdd.4401500" @default.
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