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• W2017258145 abstract "Conflicting results have been published concerning the role of apoptosis impairment in cytotoxic drug resistance. This has shed important doubts on the currently accepted dogma, which presents apoptosis as a universal determinant of drug activity. These differing results are likely to be related to the cell-type specificity of apoptotic pathways. New genetic tools have recently been made available for the study of anticancer drug resistance. Differential or subtractive analyses of gene expression, especially using cDNA microarrays, allow the identification of multiple genes and complex pathways involved in drug activity, and the use of genetic suppressor elements represents a functional approach for the identification of resistance genes." @default.
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• W2017258145 creator A5023858440 @default.
• W2017258145 date "2001-08-01" @default.
• W2017258145 modified "2023-09-26" @default.
• W2017258145 title "Resistance to cytotoxic agents" @default.
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• W2017258145 doi "https://doi.org/10.1016/s1471-4892(01)00061-3" @default.
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